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FLASH GENE
Symbol DLEC1 contributors: mct - updated : 14-06-2010
HGNC name deleted in lung and esophageal cancer 1
HGNC id 2899
Location 3p22.2      Physical location : 38.080.695 - 38.164.228
Synonym name
  • tumor suppressor gene(s),chromosome 3 (see also SEMA3B)
  • deleted in lung cancer protein 1
  • Synonym symbol(s) DLC1, F56, H37, TSG3C
    DNA
    TYPE functioning gene
    STRUCTURE 83.53 kb     36 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D3S1307 - D3S1270 - D3S1297 - D3S1560 - D3S1304 - D3S1597 - D3S1259 - {D3S1585 - D3S1286} - D3S3866 - D3S2977 - D3S4103 - D3S1293 - D3S1283 - D3S1609 - D3S1277 - D3S1298 - D3S1613 - D3S1573 - D3S1581 - [D3S1606 - D3S1295 - D3S2387 - D3S1592 - D3S2452 - D3S1766 - D3S1313 - D3S1547 - D3S3862 - D3S1234 - D3S4482 - D3S1300 - D3S1312 - D3S1600 - D3S1481 - D3S4489 -D3S4260 - D3S4483 - D3S1480 ] - D3S1285 - D3S1228 - D3S1217 - D3S1210 - D3S1284 - D3S2540 - D3S2539 - D3S2512 - (D3S1274 - D3S2498 ) - D3S2503 - D3S1604 - D3S1577 - D3S1277 - D3S1276 - D3S1595 - (D3S1552 - D3S1251 ) - D3S1603 - cen
    Text [TSG3C ], {breast carcinoma}, ((ROBO1 ))
    Physical map
    KIAA0342 3p24.2-p23 cardiomyopathy associated 1 LOC389106 3 LOC389106 LOC389107 3 similar to Hsp70/Hsp90 organizing protein homolog CG2720-PA LOC389108 3 LOC389108 LOC391527 3 similar to chromosome 2 open reading frame 7 EPM2AIP1 3p22.1 EPM2A (laforin) interacting protein 1 MLH1 3p21.3 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) LRRFIP2 3p24.3-p23 leucine rich repeat (in FLII) interacting protein 2 FLJ31715 3p22.1 hypothetical protein FLJ31715 GOLGA4 3p22-p21.3 golgi autoantigen, golgin subfamily a, 4 APRG1 3p22.1 AP20 region protein ITGA9 3p21.3 integrin, alpha 9 CTDSPL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like VILL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like PLCD1 3p21.3 phospholipase C, delta 1 DLEC1 ACAA1 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) MYD88 3p22-p21.3 myeloid differentiation primary response gene (88) OSR1 3p22-p21.3 oxidative-stress responsive 1 SLC22A13 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 13 SLC22A14 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 14 XYLB 3p22-p21.3 xylulokinase homolog (H. influenzae) ACVR2B 3p22 activin A receptor, type IIB ENDOGL1 3p21.3 endonuclease G-like 1 LOC391528 3 similar to ribosomal protein L18a; 60S ribosomal protein L18a SCN5A 3p21 sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) SCN10A 3p21-p22 sodium channel, voltage-gated, type X, alpha SCN11A 3p24-p21 sodium channel, voltage-gated, type XI, alpha KIAA1449 3p21.33 WD repeat endosomal protein GORASP1 3p22-p21.33 golgi reassembly stacking protein 1, 65kDa STI2 3p21.33 TPR domain containing STI2 AXUD1 3p22 AXIN1 up-regulated 1 CMYA1 3p21.33 cardiomyopathy associated 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 5632 195 1755 - 1999 10213508
    also called DLEC1-N1
    - - 5524 63 559 - 1999 10213508
    also called DLEC1-S1
    - - 5422 72 640 - 1999 10213508
    also called DLEC1-S2
    36 - 5508 197 1778 - 1999 10213508
    also called DLEC1-S3
    - - 6436 80 711 - 1999 10213508
    also called DLEC1-L1
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • tumor suppressor gene(s), putatively involved in regulation of the expression of the telomere (see DRR1)
  • candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma
  • functional tumour suppressor, being frequently silenced by epigenetic mechanism in gastrointestinal tumours
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in malignant melanoma, renal cell carcinoma, cervical precancer, breast cancer lung cancer, gastrointestinal tumor, Merkel cell carcinoma nasopharyngeal carcinoma, head and neck cancer
    tumoral   LOH    
    in nasopharyngeal carcinoma, esophageal cancer, renal cell carcinoma, lung cancer, bronchial cancer, esophageal squamous cell carcinoma,
    tumoral   LOH    
    in pancreatic islet cell tumors, head and neck cancer, cervix tumor, non small cell lung carcinoma, primary brain tumor, adenocarcinoma
    tumoral   translocation    
    in renal carcinoma
    tumoral somatic mutation      
    in prostate cancer, uterine endometrium
    tumoral       loss of function
    in lung and breast cancer and preinvasive bronchial lesion
    tumoral     --low  
    in renal cell carcinoma, gastric carcinoma
    tumoral     --low  
    downregulated by promoter hypermethylation and histone hypoacetylation in epithelial ovarian cancer
    tumoral     --low  
    or silenced in most colorectal and gastric cell lines due to promoter methylation, whereas broadly expressed in normal tissues including colon and stomach, and unmethylated in expressing cell lines and immortalised normal colon epithelial cells
    tumoral     --low  
    by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis
    tumoral     --low  
    by promoter methylation, associated with poor prognosis in non-small cell lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC
    Marker
    Therapy target
    ANIMAL & CELL MODELS