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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

DLEC1

contributors: mct - updated : 14-06-2010

HGNC name	deleted in lung and esophageal cancer 1
HGNC id	2899

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007335 37 - 5632 NP_031361 195 1755 - 1999 10213508 also called DLEC1-N1 variant 2 - - 5524 isoform 2 63 559 - 1999 10213508 also called DLEC1-S1 variant 3 - - 5422 isoform 3 72 640 - 1999 10213508 also called DLEC1-S2 NM_007337 36 - 5508 NP_031363 197 1778 - 1999 10213508 also called DLEC1-S3 variant 1 - - 6436 isoform 1 80 711 - 1999 10213508 also called DLEC1-L1

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Respiratory epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	tumor suppressor gene(s), putatively involved in regulation of the expression of the telomere (see DRR1)
	candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma
	functional tumour suppressor, being frequently silenced by epigenetic mechanism in gastrointestinal tumours

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in malignant melanoma, renal cell carcinoma, cervical precancer, breast cancer lung cancer, gastrointestinal tumor, Merkel cell carcinoma nasopharyngeal carcinoma, head and neck cancer tumoral   LOH     in nasopharyngeal carcinoma, esophageal cancer, renal cell carcinoma, lung cancer, bronchial cancer, esophageal squamous cell carcinoma, tumoral   LOH     in pancreatic islet cell tumors, head and neck cancer, cervix tumor, non small cell lung carcinoma, primary brain tumor, adenocarcinoma tumoral   translocation     in renal carcinoma tumoral somatic mutation       in prostate cancer, uterine endometrium tumoral       loss of function in lung and breast cancer and preinvasive bronchial lesion tumoral     --low   in renal cell carcinoma, gastric carcinoma tumoral     --low   downregulated by promoter hypermethylation and histone hypoacetylation in epithelial ovarian cancer tumoral     --low   or silenced in most colorectal and gastric cell lines due to promoter methylation, whereas broadly expressed in normal tissues including colon and stomach, and unmethylated in expressing cell lines and immortalised normal colon epithelial cells tumoral     --low   by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis tumoral     --low   by promoter methylation, associated with poor prognosis in non-small cell lung carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene	DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC
Marker
Therapy target

ANIMAL & CELL MODELS