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FLASH GENE
Symbol DLEC1 contributors: mct - updated : 14-06-2010
HGNC name deleted in lung and esophageal cancer 1
HGNC id 2899
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • tumor suppressor gene(s), putatively involved in regulation of the expression of the telomere (see DRR1)
  • candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma
  • functional tumour suppressor, being frequently silenced by epigenetic mechanism in gastrointestinal tumours
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in malignant melanoma, renal cell carcinoma, cervical precancer, breast cancer lung cancer, gastrointestinal tumor, Merkel cell carcinoma nasopharyngeal carcinoma, head and neck cancer
    tumoral   LOH    
    in nasopharyngeal carcinoma, esophageal cancer, renal cell carcinoma, lung cancer, bronchial cancer, esophageal squamous cell carcinoma,
    tumoral   LOH    
    in pancreatic islet cell tumors, head and neck cancer, cervix tumor, non small cell lung carcinoma, primary brain tumor, adenocarcinoma
    tumoral   translocation    
    in renal carcinoma
    tumoral somatic mutation      
    in prostate cancer, uterine endometrium
    tumoral       loss of function
    in lung and breast cancer and preinvasive bronchial lesion
    tumoral     --low  
    in renal cell carcinoma, gastric carcinoma
    tumoral     --low  
    downregulated by promoter hypermethylation and histone hypoacetylation in epithelial ovarian cancer
    tumoral     --low  
    or silenced in most colorectal and gastric cell lines due to promoter methylation, whereas broadly expressed in normal tissues including colon and stomach, and unmethylated in expressing cell lines and immortalised normal colon epithelial cells
    tumoral     --low  
    by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis
    tumoral     --low  
    by promoter methylation, associated with poor prognosis in non-small cell lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC
    Marker
    Therapy target
    ANIMAL & CELL MODELS