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FLASH GENE
Symbol DIS3L contributors: mct - updated : 08-07-2013
HGNC name DIS3 mitotic control homolog (S. cerevisiae)-like
HGNC id 28698
Location 15q22.31      Physical location : 66.585.632 - 66.626.235
Synonym name
  • DIS3-like exonuclease 1
    • Synonym symbol(s) KIAA1955, MGC4562, FLJ38088, DIS3L1
    EC.number 3.1.13.-
    DNA
    TYPE functioning gene
    STRUCTURE 40.60 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3714 111 971 - 2010 20531389
    17 - 3795 - 1054 - 2010 20531389
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Reproductivefemale systemuteruscervix predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RNB domain seemed to mediate its activity
    • HOMOLOGY
    interspecies homolog to rattus Dis3l (91.6 pc)
    homolog to murine Dis3l (92.1 pc)
    intraspecies paralog to DIS3L2, DIS3
    Homologene
    FAMILY
  • ribonuclease II (RNB) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • exclusively localized to the cytoplasm
    • basic FUNCTION
  • DIS3 and DIS3L are active exonucleases, but, only DIS3 has retained endonucleolytic activity
  • exosome-associated exoribonuclease
  • novel exosome-associated exoribonuclease in the cytoplasm of human cells
  • DIS3L2, DIS3 and DIS3L, have exoribonuclease activity and bind to the core RNA exosome complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • associate with the exosome core
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS