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FLASH GENE
Symbol DIS3L contributors: mct - updated : 08-07-2013
HGNC name DIS3 mitotic control homolog (S. cerevisiae)-like
HGNC id 28698
DNA
TYPE functioning gene
STRUCTURE 40.60 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3714 111 971 - 2010 20531389
17 - 3795 - 1054 - 2010 20531389
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Reproductivefemale systemuteruscervix predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RNB domain seemed to mediate its activity
  • HOMOLOGY
    interspecies homolog to rattus Dis3l (91.6 pc)
    homolog to murine Dis3l (92.1 pc)
    intraspecies paralog to DIS3L2, DIS3
    Homologene
    FAMILY
  • ribonuclease II (RNB) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • exclusively localized to the cytoplasm
  • basic FUNCTION
  • DIS3 and DIS3L are active exonucleases, but, only DIS3 has retained endonucleolytic activity
  • exosome-associated exoribonuclease
  • novel exosome-associated exoribonuclease in the cytoplasm of human cells
  • DIS3L2, DIS3 and DIS3L, have exoribonuclease activity and bind to the core RNA exosome complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • associate with the exosome core
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS