Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DIS3L contributors: mct - updated : 08-07-2013
HGNC name DIS3 mitotic control homolog (S. cerevisiae)-like
HGNC id 28698
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RNB domain seemed to mediate its activity
    • HOMOLOGY
    interspecies homolog to rattus Dis3l (91.6 pc)
    homolog to murine Dis3l (92.1 pc)
    intraspecies paralog to DIS3L2, DIS3
    Homologene
    FAMILY
  • ribonuclease II (RNB) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • exclusively localized to the cytoplasm
    • basic FUNCTION
  • DIS3 and DIS3L are active exonucleases, but, only DIS3 has retained endonucleolytic activity
  • exosome-associated exoribonuclease
  • novel exosome-associated exoribonuclease in the cytoplasm of human cells
  • DIS3L2, DIS3 and DIS3L, have exoribonuclease activity and bind to the core RNA exosome complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • associate with the exosome core
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS