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FLASH GENE
Symbol DHX37 contributors: mct - updated : 10-09-2019
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 37
HGNC id 17210
Corresponding disease
GDTRS 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome
NDDNA neurodevelopmental disorder, with neurologic anomalies
Location 12q24.32      Physical location : 125.431.372 - 125.473.667
Synonym name
  • DEAD/DEAH box helicase DDX37
  • DEAH box protein 37
  • Synonym symbol(s) MGC2695, MGC4322, KIAA1517, DDX37, MGC46245, Dhr1
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 42.31 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 4559 129 1157 - 2011 21873635
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DEAD /H box
  • helicase conserved C terminal domain
  • an helicase associated domain
  • C-terminal domain essential for DHX37 function in ribosome biogenesis , is required, but not sufficient, for interaction with UTP14A in vitro and is essential for ribosome biogenesis
  • HOMOLOGY
    interspecies homolog to Drosophila Lk6
    homolog to C.elegans R166.5
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • having nucleic acid binding, helicase, ATP binding activities
  • essential for ribosome biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • conserved sequence motif in UTP14A interacts with and activates DHX37 by stimulating its ATPase activity and enhancing RNA binding
  • cell & other
    REGULATION
    activated by is activated by the ribosome biogenesis factor UTP14A to facilitate maturation of the small ribosomal subunit
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDNA , GDTRS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS