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FLASH GENE

Symbol

DHX37

contributors: mct - updated : 10-09-2019

HGNC name	DEAH (Asp-Glu-Ala-His) box polypeptide 37
HGNC id	17210

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032656 27 - 4559 NP_116045 129 1157 - 2011 21873635

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DEAD /H box
	helicase conserved C terminal domain
	an helicase associated domain
	C-terminal domain essential for DHX37 function in ribosome biogenesis , is required, but not sufficient, for interaction with UTP14A in vitro and is essential for ribosome biogenesis

HOMOLOGY

interspecies	homolog to Drosophila Lk6
	homolog to C.elegans R166.5

Homologene

FAMILY	DEAD box helicase family
	DEAH subfamily

CATEGORY

enzyme , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	having nucleic acid binding, helicase, ATP binding activities
	essential for ribosome biogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

conserved sequence motif in UTP14A interacts with and activates DHX37 by stimulating its ATPase activity and enhancing RNA binding

cell & other

REGULATION

activated by

is activated by the ribosome biogenesis factor UTP14A to facilitate maturation of the small ribosomal subunit

ASSOCIATED DISORDERS

corresponding disease(s)

NDDNA , GDTRS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS