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FLASH GENE
Symbol DHX37 contributors: mct - updated : 10-09-2019
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 37
HGNC id 17210
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD /H box
  • helicase conserved C terminal domain
  • an helicase associated domain
  • C-terminal domain essential for DHX37 function in ribosome biogenesis , is required, but not sufficient, for interaction with UTP14A in vitro and is essential for ribosome biogenesis
    • HOMOLOGY
    interspecies homolog to Drosophila Lk6
    homolog to C.elegans R166.5
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • having nucleic acid binding, helicase, ATP binding activities
  • essential for ribosome biogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • conserved sequence motif in UTP14A interacts with and activates DHX37 by stimulating its ATPase activity and enhancing RNA binding
    • cell & other
    REGULATION
    activated by is activated by the ribosome biogenesis factor UTP14A to facilitate maturation of the small ribosomal subunit
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDNA , GDTRS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS