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FLASH GENE

Symbol

CYP2C9

contributors: mct - updated : 17-11-2021

HGNC name	cytochrome P450, family 2, subfamily C, polypeptide 9
HGNC id	2623

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q23.33      Physical location : 96.698.414 - 96.749.147
Synonym name	cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10
	microsomal monooxygenase
	cytochrome P-450 S-mephenytoin 4-hydroxylase
	flavoprotein-linked monooxygenase
Synonym symbol(s)	MGC149605 CPC9, CYP2C, CYP2C10, MGC88320, P450 MP-4, P450 PB-1, CYPIIC9, P450-2C9, P450IIC9
EC.number	1.14.14.1/ 1.14.14.52/1.14.14.53

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	51.43 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

N

status

confirmed

Map	cen - CYP2C18 - CYP2C19 - CYP2C9 - CYP2C8 - qter
Authors	Gray et al (95)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000771 9 - 2561 NP_000762 - 490 - 2021 34638547

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal ER-transmembrane domain
	a large, cytoplasmic catalytic domain

conjugated

HemoP

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY	cytochrome P450 subfamily IIC
	multigenic cytochrome P450 superfamily of mixed-function monooxygenases

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	involved in an NADPH-dependent electron transport pathway and oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
	hydroxylating many xenobiotics inducing phenytoin, S-warfarin, and tolbutamide
	CYP2C9 and CYP2C19 are important drug-metabolizing enzymes and together metabolize approximately 20 p100 of therapeutically used drugs
	cytochrome P450 enzyme responsible for metabolizing up to 15 p100 of small molecule drugs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport , detoxification

PATHWAY

metabolism

drug

signaling

oxidative metabolism

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH, heme

protein

flavoprotein P450 oxidoreductase (POR)

cell & other

REGULATION

induced by

rifampin

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

Human Cytochrome P450 (CYP) Allele Nomenclature Committee

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in multiple cohorts of human esophageal squamous cell carcinoma (ESCC)

Susceptibility

to adverse drug reactions/toxicities when drugs extensively metabolized by CYP2C9 to warfarin resistance to variation of the metabolism of warfarin and other drugs

Variant & Polymorphism SNP , other	variability interindividual and ethnic
	increasing the warfarin resistance
	CYP2C9 variants have significantly decreased function and have the potential to impact the metabolism of warfarin and other drugs

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive oesophagus Overexpression of CYP2C9 reduced the invasion and migration of esophageal squamous cell carcinoma (ESCC) cells

ANIMAL & CELL MODELS