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FLASH GENE
Symbol CYP2C9 contributors: mct - updated : 17-11-2021
HGNC name cytochrome P450, family 2, subfamily C, polypeptide 9
HGNC id 2623
Location 10q23.33      Physical location : 96.698.414 - 96.749.147
Synonym name
  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10
  • microsomal monooxygenase
  • cytochrome P-450 S-mephenytoin 4-hydroxylase
  • flavoprotein-linked monooxygenase
  • Synonym symbol(s) MGC149605 CPC9, CYP2C, CYP2C10, MGC88320, P450 MP-4, P450 PB-1, CYPIIC9, P450-2C9, P450IIC9
    EC.number 1.14.14.1/ 1.14.14.52/1.14.14.53
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 51.43 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked N status confirmed
    Map cen - CYP2C18 - CYP2C19 - CYP2C9 - CYP2C8 - qter
    Authors Gray et al (95)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2561 - 490 - 2021 34638547
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal ER-transmembrane domain
  • a large, cytoplasmic catalytic domain
  • conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIC
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in an NADPH-dependent electron transport pathway and oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
  • hydroxylating many xenobiotics inducing phenytoin, S-warfarin, and tolbutamide
  • CYP2C9 and CYP2C19 are important drug-metabolizing enzymes and together metabolize approximately 20 p100 of therapeutically used drugs
  • cytochrome P450 enzyme responsible for metabolizing up to 15 p100 of small molecule drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by rifampin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in multiple cohorts of human esophageal squamous cell carcinoma (ESCC)
    Susceptibility
  • to adverse drug reactions/toxicities when drugs extensively metabolized by CYP2C9
  • to warfarin resistance
  • to variation of the metabolism of warfarin and other drugs
  • Variant & Polymorphism SNP , other
  • variability interindividual and ethnic
  • increasing the warfarin resistance
  • CYP2C9 variants have significantly decreased function and have the potential to impact the metabolism of warfarin and other drugs
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    Overexpression of CYP2C9 reduced the invasion and migration of esophageal squamous cell carcinoma (ESCC) cells
    ANIMAL & CELL MODELS