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FLASH GENE

Symbol

CYP2C9

contributors: mct - updated : 17-11-2021

HGNC name	cytochrome P450, family 2, subfamily C, polypeptide 9
HGNC id	2623

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

Human Cytochrome P450 (CYP) Allele Nomenclature Committee

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in multiple cohorts of human esophageal squamous cell carcinoma (ESCC)

Susceptibility

to adverse drug reactions/toxicities when drugs extensively metabolized by CYP2C9 to warfarin resistance to variation of the metabolism of warfarin and other drugs

Variant & Polymorphism SNP , other	variability interindividual and ethnic
	increasing the warfarin resistance
	CYP2C9 variants have significantly decreased function and have the potential to impact the metabolism of warfarin and other drugs

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive oesophagus Overexpression of CYP2C9 reduced the invasion and migration of esophageal squamous cell carcinoma (ESCC) cells

ANIMAL & CELL MODELS