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FLASH GENE
Symbol CYC1 contributors: mct/ - updated : 23-06-2012
HGNC name cytochrome c-1
HGNC id 2579
Corresponding disease
CMP3D3 complex III mitochondrial deficiency 3
Location 8q24.3      Physical location : 145.149.959 - 145.152.427
Synonym name
  • subunit of the mitochondrial bc1 complex III of mitochondrial respiratory chain,oxidative phosphorylation(OXPHOS)
  • complex III subunit IV
  • ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
  • Synonym symbol(s) UQCR4
    DNA
    TYPE functioning gene
    STRUCTURE 2.47 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • SSPN constitutively recruited to the CYC1 promoter, although levels of transcription from this gene, which is regulated postrecruitment of RNAPII, are low
  • lacks typical transcriptional regulatory sequence elements such as TATA and CAAT boxes but contains seven putative GC boxes (Sp1 binding sites) and several sequences that resemble another type of the Sp1 responsive element, the enhancer core consensus sequence, the AP-1 responsive element, and the cAMP- and phorbol ester-inducible element
  • MAPPING cloned Y linked N status confirmed
    Physical map
    LOC286075 8q24.3 hypothetical protein LOC286075 LOC286076 8q24.3 similar to hypothetical protein ERK8  extracellular signal-regulated kinase 8 FLJ46072 8q24.3 FLJ46072 protein LOC389695 8 LOC389695 LOC389696 8 LOC389696 LOC286080 8q24.3 similar to CG3104-PA SCRIB 8q24.3 similar to CG3104-PA SIAHBP1 8q24.2-qtel similar to CG3104-PA LOC340371 8q24.3 hypothetical protein LOC340371 LOC389697 8 similar to epiplakin LOC392274 8 similar to cDNA sequence BC024139 PLEC1 8q24 plectin 1, intermediate filament binding protein 500kDa FLJ14464 8q24.3 hypothetical protein FLJ14464 GRINA 8q24 glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) MGC61633 8q24.3 similar to Putative protein C21orf56 LOC392275 8 similar to sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) OPLAH 8q24 5-oxoprolinase (ATP-hydrolysing) RRP41 8q24.3 exosome complex exonuclease RRP41 GPAA1 8q24.3 GPAA1P anchor attachment protein 1 homolog (yeast) CYC1 8q24.3 cytochrome c-1 DKFZP434N1923 8q24.3 hypothetical protein DKFZp434N1923 MAF1 8q24.3 homolog of yeast MAF1 KIAA1875 8q24.3 hypothetical protein KIAA1875 LOC51236 8q24.3 brain protein 16 LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1235 35.3 325 - 1989 2536365
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans C54 G4-8
    Homologene
    FAMILY
  • cytochrome C family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    text released from mitochondria during apoptosis
    basic FUNCTION
  • mediating the transfer of an electron from Rieske,FE-S protein to cytochrome C
  • is a subunit of mitochondria complex III, which is a component of mitochondrial respiratory chain and a major source of reactive oxygen species (ROS) production under both physiological and pathological conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text mitochondrial electron transfer
    PATHWAY
    metabolism
    signaling
    a component
  • component of the of the apoptosis with SMAC, APAF1 and CASP9, after release from mitochondria
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRG1 is the first extracellular ligand for CYC1 that has been identified
  • CYC1 is an NGB-interacting molecule
  • cell & other
    REGULATION
    Other potentially released from the mitochondria through a channel formed by BAX and BAK oligomers in the mitochondrial outer membrane
    ASSOCIATED DISORDERS
    corresponding disease(s) CMP3D3
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS