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FLASH GENE
Symbol CYC1 contributors: mct/ - updated : 23-06-2012
HGNC name cytochrome c-1
HGNC id 2579
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1235 35.3 325 - 1989 2536365
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans C54 G4-8
Homologene
FAMILY
  • cytochrome C family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    text released from mitochondria during apoptosis
    basic FUNCTION
  • mediating the transfer of an electron from Rieske,FE-S protein to cytochrome C
  • is a subunit of mitochondria complex III, which is a component of mitochondrial respiratory chain and a major source of reactive oxygen species (ROS) production under both physiological and pathological conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text mitochondrial electron transfer
    PATHWAY
    metabolism
    signaling
    a component
  • component of the of the apoptosis with SMAC, APAF1 and CASP9, after release from mitochondria
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRG1 is the first extracellular ligand for CYC1 that has been identified
  • CYC1 is an NGB-interacting molecule
  • cell & other
    REGULATION
    Other potentially released from the mitochondria through a channel formed by BAX and BAK oligomers in the mitochondrial outer membrane
    ASSOCIATED DISORDERS
    corresponding disease(s) CMP3D3
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS