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FLASH GENE
Symbol CYC1 contributors: mct/ - updated : 23-06-2012
HGNC name cytochrome c-1
HGNC id 2579
DNA
TYPE functioning gene
STRUCTURE 2.47 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • SSPN constitutively recruited to the CYC1 promoter, although levels of transcription from this gene, which is regulated postrecruitment of RNAPII, are low
  • lacks typical transcriptional regulatory sequence elements such as TATA and CAAT boxes but contains seven putative GC boxes (Sp1 binding sites) and several sequences that resemble another type of the Sp1 responsive element, the enhancer core consensus sequence, the AP-1 responsive element, and the cAMP- and phorbol ester-inducible element
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1235 35.3 325 - 1989 2536365
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans C54 G4-8
    Homologene
    FAMILY
  • cytochrome C family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    text released from mitochondria during apoptosis
    basic FUNCTION
  • mediating the transfer of an electron from Rieske,FE-S protein to cytochrome C
  • is a subunit of mitochondria complex III, which is a component of mitochondrial respiratory chain and a major source of reactive oxygen species (ROS) production under both physiological and pathological conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text mitochondrial electron transfer
    PATHWAY
    metabolism
    signaling
    a component
  • component of the of the apoptosis with SMAC, APAF1 and CASP9, after release from mitochondria
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRG1 is the first extracellular ligand for CYC1 that has been identified
  • CYC1 is an NGB-interacting molecule
  • cell & other
    REGULATION
    Other potentially released from the mitochondria through a channel formed by BAX and BAK oligomers in the mitochondrial outer membrane
    ASSOCIATED DISORDERS
    corresponding disease(s) CMP3D3
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS