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FLASH GENE
Symbol CXCL11 contributors: mct/npt - updated : 16-09-2009
HGNC name chemokine (C-X-C motif) ligand 11
HGNC id 10638
Location 4q21.1      Physical location : 76.954.841 - 76.957.233
Synonym name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 11
  • interferon-inducible T-cell alpha chemoattractant
  • small inducible cytokine B11
  • Synonym symbol(s) SCYB9B, SCYB11, IP9, ITAC, H174, b-R1, Beta-R1, MGC102770
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text contained in a minicluster on chromosome
    STRUCTURE 2.39 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - IL8 - CXCL1 /PPBP /PF4 - CXCL5 /CXCL6 - CXCL2 /CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
    Authors O'Donovan(99)
    Physical map
    BTC 4q13-q21 betacellulin DKFZP564O0823 4q13.3-q21.3 DKFZP564O0823 protein FLJ23604 4q21.21 hypothetical protein FLJ23604 ZNF363 4q21.1 zinc finger protein 363 THAP6 4q21.21 THAP domain containing 6 FLJ23657 4q21.21 hypothetical protein FLJ23657 CDKL2 4q21.21 cyclin-dependent kinase-like 2 (CDC2-related kinase) G3BP2 4q12-q21.1 cyclin-dependent kinase-like 2 (CDC2-related kinase) VDP 4q21.1 vesicle docking protein p115 PPEF2 4q13-q21 protein phosphatase, EF hand calcium-binding domain 2 ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - - 68 - Cox (2008)
  • also called CXCL11-(5-73)
  • CXCR3 antagonist and interestingly shows enhanced affinity to heparin
  • 4 - 1493 - 94 - Cole (1998)
    - - - - 58 - Cox (2008)
    also called CXCL11-(5-63)
    - - - - 53 - Cox (2008)
    also called CXCL11-(5-58)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     salivary gland    
    Reproductivefemale systembreast   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunenatural killer
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Cxcl11
    intraspecies homolog to MIG,INP10,highly
    Homologene
    FAMILY
  • intercrine alpha (chemokine CxC) family
  • (small inducible cytokine,chemokine alpha), CXC subfamily
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing an important role in CNS diseases which involve T cell recruitment
  • key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis (Yates 2008)
  • matrix metalloproteinase processing of CXCL11 results in loss of chemoattractant activity and altered glycosaminoglycan binding (Cox 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • most dominant physiological inducer of adhesion, migration, and internalization of CXCR3 (Dagan-Berger 2006)
  • ACKR3 binds the chemokines CXCL12 and CXCL11
  • cell & other
    REGULATION
    induced by IFN gamma (IFN-gamma promotes implantation by stimulating endometrial epithelial cells (EEC) to produce CXCL11, which induces migration of trophoblast cells and T cells, proliferation of endometrial stromal cells, and apoptosis of EEC) (Hirota 2006)
    Other cleavage of the N-terminal two residues by DPP8
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the salivary glands of Sjögren syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS