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FLASH GENE
Symbol CXCL11 contributors: mct/npt - updated : 16-09-2009
HGNC name chemokine (C-X-C motif) ligand 11
HGNC id 10638
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cxcl11
intraspecies homolog to MIG,INP10,highly
Homologene
FAMILY
  • intercrine alpha (chemokine CxC) family
  • (small inducible cytokine,chemokine alpha), CXC subfamily
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing an important role in CNS diseases which involve T cell recruitment
  • key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis (Yates 2008)
  • matrix metalloproteinase processing of CXCL11 results in loss of chemoattractant activity and altered glycosaminoglycan binding (Cox 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • most dominant physiological inducer of adhesion, migration, and internalization of CXCR3 (Dagan-Berger 2006)
  • ACKR3 binds the chemokines CXCL12 and CXCL11
  • cell & other
    REGULATION
    induced by IFN gamma (IFN-gamma promotes implantation by stimulating endometrial epithelial cells (EEC) to produce CXCL11, which induces migration of trophoblast cells and T cells, proliferation of endometrial stromal cells, and apoptosis of EEC) (Hirota 2006)
    Other cleavage of the N-terminal two residues by DPP8
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the salivary glands of Sjögren syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS