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FLASH GENE
Symbol CXCL11 contributors: mct/npt - updated : 16-09-2009
HGNC name chemokine (C-X-C motif) ligand 11
HGNC id 10638
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 salivary gland    
Reproductivefemale systembreast   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunenatural killer
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cxcl11
intraspecies homolog to MIG,INP10,highly
Homologene
FAMILY
  • intercrine alpha (chemokine CxC) family
  • (small inducible cytokine,chemokine alpha), CXC subfamily
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing an important role in CNS diseases which involve T cell recruitment
  • key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis (Yates 2008)
  • matrix metalloproteinase processing of CXCL11 results in loss of chemoattractant activity and altered glycosaminoglycan binding (Cox 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • most dominant physiological inducer of adhesion, migration, and internalization of CXCR3 (Dagan-Berger 2006)
  • ACKR3 binds the chemokines CXCL12 and CXCL11
  • cell & other
    REGULATION
    induced by IFN gamma (IFN-gamma promotes implantation by stimulating endometrial epithelial cells (EEC) to produce CXCL11, which induces migration of trophoblast cells and T cells, proliferation of endometrial stromal cells, and apoptosis of EEC) (Hirota 2006)
    Other cleavage of the N-terminal two residues by DPP8
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the salivary glands of Sjögren syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS