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FLASH GENE
Symbol CTDSPL contributors: mct/npt - updated : 04-02-2009
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
HGNC id 16890
Location 3p22.2      Physical location : 37.903.668 - 38.025.959
Synonym name
  • sequence homolog to yeast hypothetical protein YA22
  • chromosome 3 open reading frame 8
  • small CTD phosphatase 3
  • HYA22 protein
  • CTDSP-like
  • NLI-interacting factor 1
  • Synonym symbol(s) HYA22, SCP3, C3orf8, RBSP3, NIF1, NIFL, RBSP3, PSR1
    EC.number 3.1.3.-
    DNA
    TYPE functioning gene
    STRUCTURE 122.30 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC205655 3p22.1 similar to hypothetical protein MGC8902 KIAA1765 3p22.1 KIAA1765 protein KIAA0342 3p24.2-p23 KIAA1765 protein LOC389106 3 LOC389106 LOC389107 3 similar to Hsp70/Hsp90 organizing protein homolog CG2720-PA LOC389108 3 LOC389108 LOC391527 3 similar to chromosome 2 open reading frame 7 EPM2AIP1 3p22.1 EPM2A (laforin) interacting protein 1 MLH1 3p21.3 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) LRRFIP2 3p24.3-p23 leucine rich repeat (in FLII) interacting protein 2 FLJ31715 3p22.1 hypothetical protein FLJ31715 GOLGA4 3p22-p21.3 golgi autoantigen, golgin subfamily a, 4 APRG1 3p22.1 AP20 region protein ITGA9 3p21.3 integrin, alpha 9 CTDSPL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like VILL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like PLCD1 3p21.3 phospholipase C, delta 1 DLEC1 ACAA1 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) MYD88 3p22-p21.3 myeloid differentiation primary response gene (88) OSR1 3p22-p21.3 oxidative-stress responsive 1 SLC22A13 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 13 SLC22A14 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 14 XYLB 3p22-p21.3 xylulokinase homolog (H. influenzae) ACVR2B 3p22 activin A receptor, type IIB ENDOGL1 3p21.3 endonuclease G-like 1 LOC391528 3 similar to ribosomal protein L18a; 60S ribosomal protein L18a SCN5A 3p21 sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) SCN10A 3p21-p22 sodium channel, voltage-gated, type X, alpha SCN11A 3p24-p21 sodium channel, voltage-gated, type XI, alpha
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 4422 - 265 - Kashuba (2004)
    lacks 11 AA (79-89)
    8 splicing 4455 - 276 - Kashuba (2004)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestine   highly
    Endocrinepancreas    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NLI-interacting factor motif
  • small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery (Kashuba 2004)
  • HOMOLOGY
    interspecies homolog to yeast hypothetical protein YA22
    ortholog to murine Ctdspl
    Homologene
    FAMILY
  • small C-terminal domain (CTD) phosphatase, SCP family
  • NLIIF family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the dephosphorylation of Ser5 within the consensus repeat of RNA polymerase II
  • may be functioning as coordinator of transcriptional activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • LDB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in major epithelial cancers
    tumoral   deletion    
    in early and late-onset breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS