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FLASH GENE
Symbol CTDSPL contributors: mct/npt - updated : 04-02-2009
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
HGNC id 16890
Location 3p22.2      Physical location : 37.903.668 - 38.025.959
Synonym name
  • sequence homolog to yeast hypothetical protein YA22
  • chromosome 3 open reading frame 8
  • small CTD phosphatase 3
  • HYA22 protein
  • CTDSP-like
  • NLI-interacting factor 1
  • Synonym symbol(s) HYA22, SCP3, C3orf8, RBSP3, NIF1, NIFL, RBSP3, PSR1
    EC.number 3.1.3.-
    DNA
    TYPE functioning gene
    STRUCTURE 122.30 kb     8 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 4422 - 265 - Kashuba (2004)
    lacks 11 AA (79-89)
    8 splicing 4455 - 276 - Kashuba (2004)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestine   highly
    Endocrinepancreas    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NLI-interacting factor motif
  • small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery (Kashuba 2004)
  • HOMOLOGY
    interspecies homolog to yeast hypothetical protein YA22
    ortholog to murine Ctdspl
    Homologene
    FAMILY
  • small C-terminal domain (CTD) phosphatase, SCP family
  • NLIIF family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the dephosphorylation of Ser5 within the consensus repeat of RNA polymerase II
  • may be functioning as coordinator of transcriptional activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • LDB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in major epithelial cancers
    tumoral   deletion    
    in early and late-onset breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS