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FLASH GENE
Symbol CTDSPL contributors: mct/npt - updated : 04-02-2009
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
HGNC id 16890
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NLI-interacting factor motif
  • small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery (Kashuba 2004)
  • HOMOLOGY
    interspecies homolog to yeast hypothetical protein YA22
    ortholog to murine Ctdspl
    Homologene
    FAMILY
  • small C-terminal domain (CTD) phosphatase, SCP family
  • NLIIF family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the dephosphorylation of Ser5 within the consensus repeat of RNA polymerase II
  • may be functioning as coordinator of transcriptional activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • LDB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in major epithelial cancers
    tumoral   deletion    
    in early and late-onset breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS