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FLASH GENE

Symbol

CTDSPL

contributors: mct/npt - updated : 15-02-2023

HGNC name	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
HGNC id	16890

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	NLI-interacting factor motif
	small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery (Kashuba 2004)

HOMOLOGY

interspecies	homolog to yeast hypothetical protein YA22
	ortholog to murine Ctdspl

Homologene

FAMILY	small C-terminal domain (CTD) phosphatase, SCP family
	NLIIF family

CATEGORY

chaperone/stress , enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus

basic FUNCTION	catalyzing the dephosphorylation of Ser5 within the consensus repeat of RNA polymerase II
	may be functioning as coordinator of transcriptional activity
	is shown to involve in regulation of cell growth and differentiation and exhibits tumor suppressor activity
	CTDSPL and CTDSPL2 have oncogenic properties, including promoting cell migration

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein	LDB1
	miR-99a regulates CTDSPL, which induces the G1/S transition by increasing Cyclin expression and play a significant role in proliferation of cord blood megakaryocytes (MKs)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in major epithelial cancers tumoral   deletion     in early and late-onset breast carcinoma tumoral fusion       with RAF1 in melanomas tumoral     --low   more pronounced in cervical tumors with lymph node metastases compared with non-metastatic ones

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS