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FLASH GENE
Symbol CTDSPL contributors: mct/npt - updated : 04-02-2009
HGNC name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
HGNC id 16890
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 4422 - 265 - Kashuba (2004)
lacks 11 AA (79-89)
8 splicing 4455 - 276 - Kashuba (2004)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestine   highly
Endocrinepancreas    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NLI-interacting factor motif
  • small C-terminal domain phosphatases that may control the RNA polymerase II transcription machinery (Kashuba 2004)
  • HOMOLOGY
    interspecies homolog to yeast hypothetical protein YA22
    ortholog to murine Ctdspl
    Homologene
    FAMILY
  • small C-terminal domain (CTD) phosphatase, SCP family
  • NLIIF family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the dephosphorylation of Ser5 within the consensus repeat of RNA polymerase II
  • may be functioning as coordinator of transcriptional activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • LDB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in major epithelial cancers
    tumoral   deletion    
    in early and late-onset breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS