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FLASH GENE

Symbol

CPA1

contributors: mct - updated : 02-05-2014

HGNC name	carboxypeptidase A1 (pancreatic)
HGNC id	2296

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q32.2      Physical location : 130.020.289 - 130.027.948
Synonym symbol(s)	CPA, CBP1
EC.number	3.4.17.1

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	member of a cluster of carboxypeptidase on chromosome 7 with CPA2, CPA4 and CPA5
STRUCTURE	7.66 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001868 10 - 1445 NP_001859 - 419 - 2002 11836249

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a leader sequence
	an activation peptide
	a carbopeptidase moiety with a zinc binding site
	a 16-AA secretory signal peptide and a 94-AA propeptide

conjugated

MetalloP

mono polymer

monomer

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Cpa

Homologene

FAMILY

zinc carboxypeptidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	cleaving substrates with C terminal hydrophobic residues
	pancreatic metalloprotease that hydrolyze C-terminal peptide bonds in dietary polypeptide chains
	CPA1, CPA2 might play a role in the renin-angiotensin system in addition to their functions as digestive enzymes
	CPA1 and CPA2 act on aromatic and aliphatic amino acid residues that are exposed by the action of chymotrypsins and elastases

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	ions zinc Zn2+ binding

protein	interacting with ELA2A
	CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation

cell & other

REGULATION

activated by

proteolytic cleavage at the C-terminal end of the propeptide by trypsin

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to nonalcoholic chronic pancreatitis

Variant & Polymorphism other	loss-of-function CPA1 variants are strongly associated with nonalcoholic chronic pancreatitis, especially early onset disease (PMId:23955596)

Candidate gene
Marker	increased pro-CPA1 and CPA1 levels is a biomarker for the diagnosis of pancreatitis and pancreatic cancer
Therapy target

ANIMAL & CELL MODELS