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FLASH GENE
Symbol CPA1 contributors: mct - updated : 02-05-2014
HGNC name carboxypeptidase A1 (pancreatic)
HGNC id 2296
Location 7q32.2      Physical location : 130.020.289 - 130.027.948
Synonym symbol(s) CPA, CBP1
EC.number 3.4.17.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of a cluster of carboxypeptidase on chromosome 7 with CPA2, CPA4 and CPA5
STRUCTURE 7.66 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1445 - 419 - 2002 11836249
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leader sequence
  • an activation peptide
  • a carbopeptidase moiety with a zinc binding site
  • a 16-AA secretory signal peptide and a 94-AA propeptide
  • conjugated MetalloP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Cpa
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • cleaving substrates with C terminal hydrophobic residues
  • pancreatic metalloprotease that hydrolyze C-terminal peptide bonds in dietary polypeptide chains
  • CPA1, CPA2 might play a role in the renin-angiotensin system in addition to their functions as digestive enzymes
  • CPA1 and CPA2 act on aromatic and aliphatic amino acid residues that are exposed by the action of chymotrypsins and elastases
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ions zinc Zn2+ binding
    protein
  • interacting with ELA2A
  • CTRC is a physiological co-activator of proCPA1 and proCPA2 and is a key regulator of digestive zymogen activation
  • cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to nonalcoholic chronic pancreatitis
    Variant & Polymorphism other
  • loss-of-function CPA1 variants are strongly associated with nonalcoholic chronic pancreatitis, especially early onset disease (PMId:23955596)
  • Candidate gene
    Marker
  • increased pro-CPA1 and CPA1 levels is a biomarker for the diagnosis of pancreatitis and pancreatic cancer
  • Therapy target
    ANIMAL & CELL MODELS