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FLASH GENE

Symbol

CP

contributors: mct - updated : 29-11-2017

HGNC name	ceruloplasmin (ferroxidase)
HGNC id	2295

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease
Location	3q25.1      Physical location : 148.890.291 - 148.939.832
Synonym name	ferroxidase
Synonym symbol(s)	CP-2
EC.number	1.16.3.1

DNA

TYPE	functioning gene
STRUCTURE	49.55 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000096 19 - 4674 NP_000087 - 1065 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual

cells

System Cell Pubmed Species Stage Rna symbol Nervous glia

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three F5/8 type A domains
	six plastocyanin-like domains

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Cp

Homologene

FAMILY

multicopper oxidase family

CATEGORY

enzyme , secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	ferroxidase, iron (II): oxygen oxidoreductase
	multicopper oxidase of plasma (Sokolov 2008)
	should provide a protective shield against inadvertent oxidant production by MPO during inflammation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	essential for iron homeostasis and neuronal survival

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	interacts with myeloperoxidase (MPO), and inhibits its peroxidase and chlorinating activity (Sokolov 2008)
	Ceruloplasmin was the predominant protein associated with MPO

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CP

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS