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FLASH GENE
Symbol CP contributors: mct - updated : 29-11-2017
HGNC name ceruloplasmin (ferroxidase)
HGNC id 2295
Corresponding disease
Location 3q25.1      Physical location : 148.890.291 - 148.939.832
Synonym name ferroxidase
Synonym symbol(s) CP-2
EC.number 1.16.3.1
DNA
TYPE functioning gene
STRUCTURE 49.55 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ZIC4 3q24 Zic family member 4 ZIC1 3q24 Zic family member 1 (odd-paired homolog, Drosophila) LOC339899 3q24 hypothetical LOC339899 LOC391586 3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 LOC344741 3q24 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389159 3 LOC389159 RPL38P1 3q21-q25 ribosomal protein L38 pseudogene 1 AGTR1 3q21-q25 angiotensin II receptor, type 1 CPB1 7p14-p13 carboxypeptidase B1 (tissue) CPA3 3q21-q25 carboxypeptidase A3 (mast cell) LOC285329 3q24 similar to Ataxin-1 ubiquitin-like interacting protein GYG 3q24 glycogenin SMARCA3 3q25.1-q26.1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 HPS3 3q24-q25.1 Hermansky-Pudlak syndrome 3 CP 3q23-q25 ceruloplasmin (ferroxidase) LOC389160 3 LOC389160 LOC116441 3q24 hypothetical protein BC014339 TM4SF1 3q21-q25 transmembrane 4 superfamily member 1 TM4SF4 3q25 transmembrane 4 superfamily member 4 TAZ Xq28 tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) LOC51122 3q25.1 HSPC042 protein LOC389161 3 hypothetical gene supported by AK027233 LOC389162 3 LOC389162 LOC389163 3 hypothetical gene supported by AK098078 RNF13 3q25.1 ring finger protein 13 PFN2 3q25.1-q25.2 profilin 2 LOC389164 3 similar to Chromosome 1 open reading frame 37 LOC391587 3 similar to peptidyl-Pro cis trans isomerase LOC389165 3 hypothetical gene supported by AF090923; AK023388; BC002719 LOC389166 3 LOC389166 KIAA0669 3q25.1-q25.2 LOC389166 SERP1 3q25.1 stress-associated endoplasmic reticulum protein 1 eIF2A 3q25.1 eukaryotic translation initiation factor (eIF) 2A SELT 3q25.1 selenoprotein T MGC39662 3q25.1 hypothetical protein MGC39662 LOC391588 3 similar to U1 small nuclear ribonucleoprotein C (U1-C) SIAH2 3q25 seven in absentia homolog 2 (Drosophila) LOC389167 3 LOC389167 USH3A 3q21-q25 Usher syndrome 3A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4674 - 1065 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three F5/8 type A domains
  • six plastocyanin-like domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cp
    Homologene
    FAMILY
  • multicopper oxidase family
  • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ferroxidase, iron (II): oxygen oxidoreductase
  • multicopper oxidase of plasma (Sokolov 2008)
  • should provide a protective shield against inadvertent oxidant production by MPO during inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text essential for iron homeostasis and neuronal survival
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacts with myeloperoxidase (MPO), and inhibits its peroxidase and chlorinating activity (Sokolov 2008)
  • Ceruloplasmin was the predominant protein associated with MPO
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS