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FLASH GENE
Symbol CP contributors: mct - updated : 29-11-2017
HGNC name ceruloplasmin (ferroxidase)
HGNC id 2295
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three F5/8 type A domains
  • six plastocyanin-like domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cp
    Homologene
    FAMILY
  • multicopper oxidase family
  • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ferroxidase, iron (II): oxygen oxidoreductase
  • multicopper oxidase of plasma (Sokolov 2008)
  • should provide a protective shield against inadvertent oxidant production by MPO during inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text essential for iron homeostasis and neuronal survival
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacts with myeloperoxidase (MPO), and inhibits its peroxidase and chlorinating activity (Sokolov 2008)
  • Ceruloplasmin was the predominant protein associated with MPO
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS