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FLASH GENE
Symbol CP contributors: mct - updated : 29-11-2017
HGNC name ceruloplasmin (ferroxidase)
HGNC id 2295
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three F5/8 type A domains
  • six plastocyanin-like domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cp
    Homologene
    FAMILY
  • multicopper oxidase family
  • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ferroxidase, iron (II): oxygen oxidoreductase
  • multicopper oxidase of plasma (Sokolov 2008)
  • should provide a protective shield against inadvertent oxidant production by MPO during inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text essential for iron homeostasis and neuronal survival
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacts with myeloperoxidase (MPO), and inhibits its peroxidase and chlorinating activity (Sokolov 2008)
  • Ceruloplasmin was the predominant protein associated with MPO
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS