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FLASH GENE
Symbol CLDN2 contributors: mct/npt/pgu - updated : 21-07-2015
HGNC name claudin 2
HGNC id 2041
Location Xq22.3      Physical location : 106.143.393 - 106.174.091
Synonym symbol(s) SP82
DNA
TYPE functioning gene
STRUCTURE 10.46 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • binding sites for CDX1, CDX2 hepatocyte nuclear factor alpha
  • promoter activity is increased by IL6 in a MEK/ERK and PI3K-dependent manner, and deletion of Cdx binding sites in the promoter sequence results in a loss of IL6-induced promoter activity
  • MAPPING cloned Y linked N status provisional
    Map cen - DXS8048 - DXS8097 - CLDN2 - DXS1504 - DXS7677 - qter
    Physical map
    LOC392515 X similar to prohibitin IL1RAPL2 Xq22 interleukin 1 receptor accessory protein-like 2 TEX13A Xq22.2-q22.3 testis expressed sequence 13A DKFZp686A17109 Xq22.3 hypothetical protein DKFZp686A17109 SERPINA7 Xq22.2 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 FLJ33516 Xq22.3 hypothetical protein FLJ33516 FLJ10178 Xq22.3 hypothetical protein FLJ10178 RNF128 Xq22.3 ring finger protein 128 FLJ20298 Xq22.3 FLJ20298 protein LOC92129 Xq22.3 hypothetical protein BC007652 CLDN2 Xq22.3-23 claudin 2 ZCWCC2 Xq22.3 zinc finger, CW-type with coiled-coil domain 2 FLJ11016 Xq22.1-24 hypothetical protein FLJ11016 FLJ20130 Xq22.3 hypothetical protein FLJ20130 MGC35261 Xq22.3 hypothetical protein MGC35261 MYCL2 Xq22.1-q22.3 v-myc myelocytomatosis viral oncogene homolog 2 (avian) LOC392516 X similar to Keratin 18 KIAA1817 Xq22 KIAA1817 protein PRPS1 Xq22-q24 phosphoribosyl pyrophosphate synthetase 1 DSIPI Xq22.3 delta sleep inducing peptide, immunoreactor LOC392517 X similar to dJ820B18.1 (similar to nuclear cap binding protein) MID2 Xq22 midline 2 NOD13 Xq22.3 NOD13 pseudogene TEX13B Xq23 testis expressed sequence 13B MGC44287 Xq22.3 hypothetical protein MGC44287 PSMD10 Xq22.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 AUTL2 Xq22.1-q22.3 AUT-like 2, cysteine endopeptidase (S. cerevisiae) COL4A6 Xq22.3 collagen, type IV, alpha 6 COL4A5 Xq22.3 collagen, type IV, alpha 5 (Alport syndrome) IRS4 Xq22.3 insulin receptor substrate 4 LOC392519 X similar to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3163 24.4 230 - 2008 18509255
    4 - 1206 - 151 - 2008 18509255
    2 - 1065 - 104 - 2008 18509255
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Hearing/Equilibriumearinnercochlea  
     earinnervestibule  
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum granulosum 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificgranular cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Cldn2
    Homologene
    FAMILY
  • claudin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • tight junction specific obliteration of the intercellular space
  • creating charge specific channels in the paracellular space
  • Ca2+ independent cell adhesion activity
  • critical role for vitamin D-dependent Ca2+ absorption between enterocytes
  • forms a cation-selective channel which confers increased permeability in renal epithelial cells and in the intestine where its expression is restricted to the leaky epithelium (
  • forms highly cation-selective paracellular pores (
  • essential mediator in the tumor-promoting role of symplekin
  • role for claudin-2 in promoting colon cancer, potentially via EGFR transactivation
  • potential functions that are relevant to neoplastic transformation and growth
  • functional mediator of breast cancer liver metastasis
  • promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes
  • regulates colorectal inflammation via MYLK
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • dimerization does not require the cytoplasmic or extracellular domains and is likely mediated through interaction of one or several of its four transmembrane segments
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGF controls the levels of CLDN2 and CLDN4 proteins and mRNAs through SRC and STAT3 activity
  • IL22 increases intestinal epithelial permeability by upregulating CLDN2 expression through the JAK/STAT pathway
  • cell & other
    REGULATION
    activated by all-trans-retinoic acid (increases the expression of claudin 2 in keratinocytes in a dose-dependent manner)
    induced by IL6 (markedly induces claudin-2 expression, which is associated with increased TJ permeability)
    Other regulated by SYMPK that depends on its functional interaction with CSDA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast carcinoma
    tumoral     --over  
    may be involved at early stages of transformation in inflammatory bowel disease -associated neoplasia
    tumoral     --over  
    may be closely correlated to gastric carcinogenesis
    constitutional     --low  
    in renal epithelial cells by metabolic acidosis
    tumoral     --over  
    in solar keratosis and skin squamous cell carcinomas compared to normal skin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS