basic FUNCTION
| tight junction specific obliteration of the intercellular space |
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creating charge specific channels in the paracellular space |
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Ca2+ independent cell adhesion activity |
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critical role for vitamin D-dependent Ca2+ absorption between enterocytes ![](pubmed.jpg) |
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forms a cation-selective channel which confers increased permeability in renal epithelial cells and in the intestine where its expression is restricted to the leaky epithelium (![](pubmed.jpg) |
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forms highly cation-selective paracellular pores ( ![](pubmed.jpg) |
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essential mediator in the tumor-promoting role of symplekin ![](pubmed.jpg) |
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role for claudin-2 in promoting colon cancer, potentially via EGFR transactivation ![](pubmed.jpg) |
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potential functions that are relevant to neoplastic transformation and growth ![](pubmed.jpg) |
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functional mediator of breast cancer liver metastasis ![](pubmed.jpg) |
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promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes ![](pubmed.jpg) |
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regulates colorectal inflammation via MYLK ![](pubmed.jpg) |