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FLASH GENE
Symbol CLDN11 contributors: mct - updated : 02-02-2022
HGNC name claudin 11
HGNC id 8514
Corresponding disease
HLD22 leukodystrophy, hypomyelinating, 22
Location 3q26.2-q26.3      Physical location : 170.136.652 - 170.152.478
Synonym name
  • oligodendrocyte transmembrane protein
  • claudin 11 (oligodendrocyte transmembrane protein)
    • Synonym symbol(s) OSP, OTM
    DNA
    TYPE functioning gene
    STRUCTURE 15.22 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2758 21.8 207 - 2021 33313762
    3 - 2445 - 123 - 2021 33313762
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivemale systemtestis  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveSertoli cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
    • HOMOLOGY
    intraspecies homolog to PMP22 (for CNS),putative
    Homologene
    FAMILY claudin family
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction,tight
    text extracellular matrix
    basic FUNCTION
  • tight junction specific obliteration of the intercelular space
  • is an obligatory protein for tight junction formation and barrier integrity in the testis
  • creating charge specific channels in the paracellular space
  • CLDN11 is a novel regulator in bone homeostasis
  • CLDN11 functions as a potential tumor suppressor gene and silencing of CLDN11 by DNA hypermethylation promotes nasopharyngeal carcinoma (NPC) progression
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text potentially involved in CNS myelogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TUBA1B and TUBB3, were identified as the novel CLDN11-interacting proteins, and CLDN11 interacted with these two tubulins through its intracellular loop and C-terminus
  • SNAI1 elicits collective migration in squamous cell carcinoma by inducing the expression of a tight junctional protein, CLDN11
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD22
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethilation in nasopharyngeal carcinoma (NPC)
    tumoral     --low  
    by hypermethylation is associated with metastasis of colorectal cancer (CRC) and prognosis of poor survival of CRC
    tumoral     --low  
    in malignant melanoma (MM) of the skin by hypermethylation
    constitutional     --over  
    in spermatogenic defect in human testes
    constitutional     --other  
    disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis
    Susceptibility to autoimmune disease (potential autoantigen in the development of autoimmune demyelinating disease)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cldn11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testisCldn11 null mice lack CNS myelin and Sertoli cell tight junction strands