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FLASH GENE

Symbol

CLDN11

contributors: mct - updated : 02-02-2022

HGNC name	claudin 11
HGNC id	8514

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Hearing/Equilibrium ear inner cochlea   highly Reproductive male system testis     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central white matter     Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Reproductive Sertoli cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four transmembrane segments

HOMOLOGY

intraspecies

homolog to PMP22 (for CNS),putative

Homologene

FAMILY

claudin family

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane,junction,tight
text	extracellular matrix

basic FUNCTION	tight junction specific obliteration of the intercelular space
	is an obligatory protein for tight junction formation and barrier integrity in the testis
	creating charge specific channels in the paracellular space
	CLDN11 is a novel regulator in bone homeostasis
	CLDN11 functions as a potential tumor suppressor gene and silencing of CLDN11 by DNA hypermethylation promotes nasopharyngeal carcinoma (NPC) progression

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	potentially involved in CNS myelogenesis

PATHWAY

metabolism

signaling

a component

major structural components of tight junction (TJ) strands

INTERACTION

DNA

RNA

small molecule

protein	TUBA1B and TUBB3, were identified as the novel CLDN11-interacting proteins, and CLDN11 interacted with these two tubulins through its intracellular loop and C-terminus
	SNAI1 elicits collective migration in squamous cell carcinoma by inducing the expression of a tight junctional protein, CLDN11

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HLD22

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethilation in nasopharyngeal carcinoma (NPC) tumoral     --low   by hypermethylation is associated with metastasis of colorectal cancer (CRC) and prognosis of poor survival of CRC tumoral     --low   in malignant melanoma (MM) of the skin by hypermethylation constitutional     --over   in spermatogenic defect in human testes constitutional     --other   disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis

Susceptibility

to autoimmune disease (potential autoantigen in the development of autoimmune demyelinating disease)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cldn11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testisCldn11 null mice lack CNS myelin and Sertoli cell tight junction strands