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FLASH GENE

Symbol

CLDN11

contributors: mct - updated : 02-02-2022

HGNC name	claudin 11
HGNC id	8514

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HLD22

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethilation in nasopharyngeal carcinoma (NPC) tumoral     --low   by hypermethylation is associated with metastasis of colorectal cancer (CRC) and prognosis of poor survival of CRC tumoral     --low   in malignant melanoma (MM) of the skin by hypermethylation constitutional     --over   in spermatogenic defect in human testes constitutional     --other   disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis

Susceptibility

to autoimmune disease (potential autoantigen in the development of autoimmune demyelinating disease)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cldn11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testisCldn11 null mice lack CNS myelin and Sertoli cell tight junction strands