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FLASH GENE
Symbol CISD2 contributors: mct - updated : 28-08-2009
HGNC name CDGSH iron sulfur domain 2
HGNC id 24212
Corresponding disease
WFS2 Wolfram syndrome 2
Location 4q24      Physical location : 103.790.134 - 103.813.961
Synonym name
  • mitoNEET related 1
  • zinc finger, CDGSH-type domain 2
  • endoplasmic reticulum intermembrane small protein
  • nutrient-deprivation autophagy factor-1
  • Synonym symbol(s) Miner1, ZCD2, ERIS, CDGSH2, STING, MITA
    DNA
    TYPE functioning gene
    STRUCTURE 19.59 kb     3 Exon(s)
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1840 15.15 135 - Amr (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal anchor sequence tethers the protein to the outer membrane
  • a single -adrenergic receptor kinase site at amino acids 25-29
  • 21 two PKA/PKC kinase motifs at amino acids 32-34 and 67-69
  • a single CK2 (formerly, casein kinase 2)
  • a 39-amino-acid single zinc-finger domain of the CDGSH type, with a CCHH finger, located close to the carboxy terminus, oriented toward the cytoplasm
  • HOMOLOGY
    Homologene
    FAMILY
  • CISD protein family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may function in Fe-S cluster shuttling and/or in redox reactions
  • important iron-containing protein involved in the control of maximal mitochondrial respiratory rates
  • endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non–self-cytosolic RNA and dsDNA (Sun 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by dimerization, induced by innate immune challenges, leads to the activation of CISD2 and, in turn, the downstream components (Sun 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) WFS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS