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FLASH GENE
Symbol CISD2 contributors: mct - updated : 01-09-2018
HGNC name CDGSH iron sulfur domain 2
HGNC id 24212
ASSOCIATED DISORDERS
corresponding disease(s) WFS2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
in cervical cancer cells at both the mRNA and protein levels
tumoral       gain of function
in lung adenocarcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • CISD2 expression might be an independent prognostic indicator for the survival of patients with early-stage cervical cancer, and might be a novel biomarker for early-stage cervical cancer progression
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    promising mitochondrial targets for cancer therapy
    diabete  
    cellular target for anti-diabetic drugs
    neuromuscularmyopathy 
    novel therapeutic target for treating certain muscle pathologies (PMID: 22343142)
    cancerdigestiveliver
    may serve as a therapeutic target for HCC
    ANIMAL & CELL MODELS
  • Cisd2 deficiency shortens lifespan resulting in premature aging in mice
  • Naf-1 null mice display discernable clinical signs of degeneration at 2-3 months of age, with early evidence of significant defects in the structure and performance of skeletal muscle