motifs/domains
| N-terminal anchor sequence tethers the protein to the outer membrane |
|
a single -adrenergic receptor kinase site at amino acids 25-29 |
|
21 two PKA/PKC kinase motifs at amino acids 32-34 and 67-69 |
|
a single CK2 (formerly, casein kinase 2) |
|
a two iron-two sulphur coordinating domain within its cytosolic region, which is necessary, but not sufficient for interaction with BCL2 |
|
a 39-amino-acid single zinc-finger domain of the CDGSH type, with a CCHH finger, located close to the carboxy terminus, oriented toward the cytoplasm |
SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,outer
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
text
| detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane |
basic FUNCTION
| may function in Fe-S cluster shuttling and/or in redox reactions |
|
important iron-containing protein involved in the control of maximal mitochondrial respiratory rates |
|
endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non–self-cytosolic RNA and dsDNA (Sun 2009) |
|
is involved in mammalian lifespan control (pMID: 20649540) |
|
endoplasmic reticulum (ER) BCL-2-interacting protein, which functions to mediate the ability of ER BCL-2 to antagonize BECN1 -dependent autophagy and depress ER calcium stores |
|
is required for homeostatic maintenance of skeletal muscle |
|
protects mitochondria from age-associated damage and functional decline as well as attenuating the age-associated reduction in whole-body energy metabolism |
|
regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis |
|
key player in regulating autophagy |
|
physiological role for CISD1, CISD2 in promoting mitochondrial function in cancer cells |
|
plays likely an important role in intracellular Ca(2+) homeostasis, which is required for the differentiation and functioning of adipocytes as well as the regulation of glucose homeostasis |
|
may function as an autophagy regulator involved in the BCL2 mediated regulation of autophagy |
|
regulates mitochondrial function, proliferation, intracellular Ca(2+) homeostasis, and Wnt pathway signaling |
|
is known to have roles in calcium metabolism, anti-apoptosis, and longevity |
|
exerts anti-apoptotic and anti-inflammatory effects in neural cells |
|
functions to control mammalian life span and regulates human cells proliferation |
|
play an important role in promoting proliferation and enhanced progression of HCC (hepatocellular carcinoma) |
|
is a redox-sensitive gene critical for normal development and mitochondrial integrity |