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FLASH GENE
Symbol CHRM3 contributors: mct/ - updated : 16-11-2011
HGNC name cholinergic receptor, muscarinic 3
HGNC id 1952
Corresponding disease
PBLS prune-belly-like syndrome
Location 1q43      Physical location : 239.792.372 - 240.072.715
Synonym name
  • m3 muscarinic receptor
  • muscarinic acetylcholine receptor M3
    • Synonym symbol(s) HM3, M3R, M3
    DNA
    TYPE functioning gene
    STRUCTURE 280.35 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LGALS8 1q42-q43 lectin, galactoside-binding, soluble, 8 (galectin 8) FLJ10359 1q42.3 protein BAP28 ACTN2 1q42-q43 actinin, alpha 2 MTR 1q43 5-methyltetrahydrofolate-homocysteine methyltransferase LOC388754 1 similar to 60S ribosomal protein L35 RYR2 1q42.1-q43 ryanodine receptor 2 (cardiac) ZP4 1q43 zona pellucida glycoprotein 4 LOC391178 1 hypothetical gene supported by AL122093 LOC391179 1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) CHRM3 1q41-q44 cholinergic receptor, muscarinic 3 LOC128136 1q43 similar to Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase) LOC284711 1q43 similar to 40S ribosomal protein S7 (S8) FMN2 1q43 formin 2 LOC266783 1q43 proteasome 26S non-ATPase subunit 2 pseudogene FLJ21195 1q43 protein related to DAN and cerberus LOC391180 1 similar to 40S ribosomal protein S11 RGS7 1q43 regulator of G-protein signalling 7 LOC388755 1 LOC388755 FH 1q42.1 fumarate hydratase KMO 1q42-q44 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) OPN3 1q43 opsin 3 (encephalopsin, panopsin) CHML 1q32-q41 choroideremia-like (Rab escort protein 2) FLJ32978 1q43 hypothetical protein FLJ32978 LOC391181 1 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) EXO1 1q43 exonuclease 1 LOC391182 1 similar to 60S ribosomal protein L23a FLJ40773 1q43 hypothetical protein FLJ40773 LOC391183 1 similar to ribosomal protein L24-like; 60S ribosomal protein L30 isolog; my024 protein; homolog of yeast ribosomal like protein 24 LOC391184 1 similar to RCC1-like LOC343365 1q43 similar to capicua homolog LOC388756 1 similar to hypothetical protein LOC349114 LOC388757 1 LOC388757 LOC339077 1q43 hypothetical gene supported by AK092558; AL137655; BC006361 KAB 1q44 KARP-1-binding protein SDCCAG8 1q44 serologically defined colon cancer antigen 8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2757 - 590 - 2011 21056967
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
    Endocrineadrenal gland   highly
    Lymphoid/Immunethymus   highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • present in developing renal epithelia and bladder muscle, and not only, but also in the urogenital sinus and fetal urethral epithelia
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
    • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • k1 cholinergic receptor
    • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • controling smooth muscle contraction and by its stimulation causes secretion of glandular tissue
  • mediating various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins
  • having a role in stimulating insulin secretion
  • major receptor involved in mediating urinary bladder contraction upon micturition
  • critical role for central CHRM3 in regulating longitudinal growth by promoting the proliferation of pituitary somatotroph cells
  • role in mediating enteric cholinergic neurotransmission
  • regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner
  • regulates many fundamental physiological functions
  • promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
  • may have a role beyond its known contribution to detrusor contractions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMEM147 is a CHRM3-associated protein (represents a potent negative regulator of M3R function, most likely by interacting with M3Rs in an intracellular compartment (ER)
  • intracellular functional link between CHRM3 and TRPM8 channel via KAT5, suggesting a novel physiological mechanism of arachidonate-mediated regulation of TRPM8 channel activity through muscarinic receptors
  • odorant receptors (ORs) and CHRM3 physically interacted, and CHRM3 increased the potency and efficacy of odorant-elicited responses of several ORs
  • interplay of CHRM3 and beta-catenin signaling is important for intestinal mucosal differentiation and neoplasia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBLS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon cancer
    Susceptibility to type 2 diabetes
    Variant & Polymorphism other polymorphisms increasing the risk of early-onset type 2 diabetes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • megacystis is present in younger Chrm3 mutant mice, and the hypocontractile bladder phenotype is very similar to humans with CHRM3 mutations