basic FUNCTION
| controling smooth muscle contraction and by its stimulation causes secretion of glandular tissue |
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mediating various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins |
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having a role in stimulating insulin secretion |
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major receptor involved in mediating urinary bladder contraction upon micturition |
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critical role for central CHRM3 in regulating longitudinal growth by promoting the proliferation of pituitary somatotroph cells |
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role in mediating enteric cholinergic neurotransmission |
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regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner |
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regulates many fundamental physiological functions |
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promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1 |
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may have a role beyond its known contribution to detrusor contractions |
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play important roles in the pathogenesis of myopia and in the arrested progression of myopia by atropine |
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major role of CHRM3 mediating the human gallbladder contraction through voltage-gated Ca(2+) channels and Rho kinase |
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preserves the endothelial barrier function through a mechanism potentially maintaining PTPN1 activity, keeping the adherens junction proteins (AJPs) dephosphorylation |
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is an acetylcholine receptor that regulates the activity of numerous fundamental central and peripheral nervous system functions |
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expression plays an important role in early progression and invasion of colon neoplasia but is less important once tumors have spread |
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in pancreatic beta cells, muscarinic cholinergic receptor M3 (CHRM3) stimulates glucose-induced secretion of insulin |
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CHRM1 and CHRM3, are essential for rapid eye movement (REM) sleep |
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M3 muscarinic acetylcholine receptor that is located on the surface of smooth muscle cells of the detrusor, the muscle that effects urinary voiding |