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FLASH GENE
Symbol CHRM3 contributors: mct/ - updated : 13-05-2020
HGNC name cholinergic receptor, muscarinic 3
HGNC id 1952
ANIMAL & CELL MODELS
  • megacystis is present in younger Chrm3 mutant mice, and the hypocontractile bladder phenotype is very similar to humans with CHRM3 mutations
  • the loss of NOSTRIN in mice leads to endothelial dysfunction, increased blood pressure, and diastolic heart failure
  • Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level