Symbol
| CHRM3
| contributors: mct/ - updated : 13-05-2020
|
HGNC name
| cholinergic receptor, muscarinic 3
|
HGNC id
| 1952
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in colon cancer | constitutional
|  
|  
|  
| gain of function
|
delayed cardiac aging by inhibiting the CASP1/IL1B signaling pathway | tumoral
|  
|  
| --over
|  
|
in colon cancer | tumoral
|  
|  
| --over
|  
|
in gastric cancer (GC) tissues and was correlated with the cancer stage and with lymph node metastasis | |
Susceptibility
|
to type 2 diabetes to elevated blood pressure (BP) |
Variant & Polymorphism
other
| polymorphisms increasing the risk of early-onset type 2 diabetes |
|
a CHRM3-coding variation increased M3R signaling, correlating with higher BP |
|
|
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
respiratory | | | |
may be important therapeutic target for obstructive airway diseases, as it regulates the effects of the epithelial-derived chemokines on airway smooth muscle (ASM) cell migration (PMID: 26956674) |
| | | |
| megacystis is present in younger Chrm3 mutant mice, and the hypocontractile bladder phenotype is very similar to humans with CHRM3 mutations | |
the loss of NOSTRIN in mice leads to endothelial dysfunction, increased blood pressure, and diastolic heart failure |
|
Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level |