motifs/domains
| a signal peptide followed by 6 immunoglobulin (Ig) domains |
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four fibronectin type III (FNIII) domains |
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a single-pass transmembrane peptide |
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a 105-amino acid cytoplasmic domain |
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21 potential N-glycosylation sites, more than 50 O-glycosylation sites |
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22 N-myristoylation sites |
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a membrane-proximal motif (RGGKYSV) in the cytoplasmic domain, having novel functions necessary for SEMA3A-induced growth cone collapse and CHL1-dependent neurite outgrowth and branching in cortical embryonic neurons (Schlatter 2008) |
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two amidation sites and multiple phosphorylation sites |
| basic FUNCTION
| neuronal adhesion protein L1-CAM serving as a receptor for nerve growth-promoting proteins |
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adhesion molecule that regulates uncoating of clathrin-coated synaptic vesicles |
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maybe involved in cognitive and behavioral functions |
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having a function in thalamic axon responsiveness to ventral telencephalic cues, and playing a role with NRP1 in establishment of proper targeting of specific thalamocortical projections (Wright 2007) |
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able to recruit ezrin, a member of the ezrin-radixin-moesin (ERM) family of filamentous actin binding proteins to the plasma membrane (Schlatter 2008) |
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promotes Purkinje and granule cell survival and granule cell migration during cerebellar development (Jakovcevski 2009) |
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important for apical dendritic projection and laminar positioning of pyramidal neurons in caudal regions of the cerebral cortex (Demyanenko 2010) |
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cooperate with PAK1, PAK2, PAK3 kinase, most likely in independent pathways, in regulating morphological development of the leading process/apical dendrite of embryonic cortical neurons (Demyanenko 2010) |
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L1CAM and CHL1, are crucial for axonal guidance and maintenance of neural circuits  |
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L1CAM and its close homolog CHL1 are neural cell adhesion molecules of the immunoglobulin superfamily |
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in the adult brain, L1CAM and CHL1 continue to play important roles in maintenance and regeneration of neural circuits |
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plays a dual role by either promoting or inhibiting neuritogenesis |
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ligand-induced and lipid raft-dependent regulation of CHL1 adhesion via Ca(2+)-dependent remodeling of the CHL1-beta2 spectrin complex and CHL1 endocytosis are required for CHL1-dependent neurite outgrowth |
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is involved in the regulation of recovery after spinal cord injury |
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is a novel intrinsic factor that is involved in carotid body (CB) function and in the ventilatory response to acute hypoxia (AH) |
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regulates neuronal migration and neurite overgrowth in the developing brain, while in mature neurons it accumulates in the axonal membrane and regulates synapse function via the clathrin-dependent pathways |
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CHL1 is a new modulator of the serotonergic system |
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DISC1 and CHL1 may engage in physical and functional interaction in neural development |
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plays important roles during nervous system development |
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roles for CHL1 in both axonal extension and repulsion, selectively of dopaminergic (DA) neurons, suggestive of a role in guidance towards forebrain targets and away from hindbrain nuclei |
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function as an important tumor suppressor with both anti-proliferation and anti-metastasis abilities, through NF2 and SEMA3B-Np1-mediated inhibition of AKT1 signaling pathway |
