| protein
| Elongin B and C ( |
|
von Hippel-Lindau binding protein 1, VBP1 ( |
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cullin 2, CUL2 ( |
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Sp1 transcription factor, Sp1 ( |
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Fibronectin ( |
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tricellulin, TRiC ( |
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Hypoxia inducible factor-alpha, HIF-alpha ( |
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heteronuclear ribonucleoprotein a2, hnRNPA2 ( |
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Hypoxia-inducible factor 1, HIF1 ( |
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VHL-interacting deubiquitinating enzyme 1, VDU1 ( |
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translocation in renal carcinoma on chromosome 8 protein, TRC8 ( |
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VDU1 and VDU2 ( |
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Jade-1 ( |
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HIF-3 alpha ( |
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hyperphosphorylated Rpb1 ( |
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RNA polymerase II subunit B7, RPB7 ( |
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Tat-binding protein-1, TBP1 ( |
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iron regulatory protein 2, IRP2 ( |
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tumorous imaginal discs protein Tid56 homolog, TID1 |
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p53 ( |
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p22phox ( |
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myogenin, MYOG ( |
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PKCzetaII ( |
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endogenously binds the neuronal kinesin-2 complex, KIF5C |
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beta(2)-adrenergic receptor, beta(2)AR ( |
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SUMO E3 ligase PIASy |
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S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, SKP2 |
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MYBBPC1A is a novel substrate of VHL |
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SOCS1-cooperative negative regulator of JAK2 |
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VHL inactivation decreases H3K4Me3 levels through KDM5C, which alters gene expression and suppresses tumor growth |
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ARF tumor suppressor interacts with VHL30, a longer VHL isoform |
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sprouty homolog 2 (Drosophila), SPRY2 |
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controls hypoxia-inducible transcription factor (HIF1A)-mediated adaptation |
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possible regulation of VHL by NEK1 that may contribute to ciliary homeostasis and cystogenesis |
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VHL is a downstream target of E2F1, which harbours an E2F1-binding site in its promoter |
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suppresses androgen-induced cell proliferation, implicating a physiological role of VHL in androgen-induced signaling pathway |
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novel function of VHL in the regulation of AR transcription activity |
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CTNNB1 links VHL to AURKA and loss of primary cilia in renal cell carcinoma |
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NEK8 may be a new HIF target gene and VHL can down-regulate NEK8 via HIFs to maintain the primary cilia structure in human renal cancer cells |
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functional RWDD3/VHL interaction in VHL-related tumor progression |
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CUL2 interacts with both the VHL BC box and cullin box and a novel ELOC site |
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ZNF350 is a novel VHL interacting protein |
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VHL is confirmed to serve as a bridge component for the association of ZNF350 and EP300, which leads to an increase in ZNF350 transcriptional activity in the VHL promoter |
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mediate the ubiquitination of HIF1A in the nuclear compartment prior to HIF1A exportation to the cytoplasm, and VHL dynamic nuclear-cytoplasmic trafficking is indicated to be involved in the process of HIF1A degradation |
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VHL/CDKN2A interaction is specifically mediated by the 53 residue long pVHL30 N-terminal region, suggesting that this N-terminus acts as a further VHL interaction interface |
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VHL is an important regulator of CERKL, and VHL ubiquitinates CERKL for proteasomal degradation |
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DAAM2 promotes tumorigenesis by suppressing VHL expression |
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ZHX2 was found as a VHL target, and its hydroxylation allowed VHL to regulate its protein stability |
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TFAM is hydroxylated by EGLN3 and subsequently bound by VHL, which stabilizes TFAM by preventing mitochondrial proteolysis |
