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FLASH GENE

Symbol

CEBPD

contributors: mct - updated : 11-02-2015

HGNC name	CCAAT/enhancer binding protein (C/EBP), delta
HGNC id	1835

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p11.21      Physical location : 48.649.475 - 48.650.726
Synonym name	nuclear factor NF-IL6-beta
	c/EBP delta
Synonym symbol(s)	CELF, CRP3, C/EBP-delta, NF-IL6-beta

DNA

TYPE	functioning gene
STRUCTURE	1.25 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - D8S136 - D8S5 - NEFL - D8S137 /D8S131 - D8S87 - FGFR1 (D8S135 ) - ANK1 - CEBPD (D8S359 ) - PLAT PLAT - cen
Authors	Wood (95)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005195 1 - 1269 NP_005186 - 269 - 2005 16192306

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   liver         Hearing/Equilibrium ear inner cochlea   highly Nervous nerve cranial nerve     highly Respiratory lung       highly Urinary kidney

cell lineage	preadipocytes
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

basic leucine zipper (bZIP) protein

HOMOLOGY

interspecies

homolog to murine Cebpd

Homologene

FAMILY	bzip family
	CUG-BP and ETR-3-like factor (CELF) family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	predominantly nuclear

basic FUNCTION	CCAAT enhancer binding protein delta (C/EBP)
	inducing conjointly with CEBPD the induction of CEBPB and PPARG, required for adipocyte differentiation
	STAT3 target and crucial mediator of pro-apoptotic gene expression events in mammary epithelial cells
	tumor suppressor because that induces growth arrest involved in differentiation and plays a crucial role as a regulator of pro-apoptotic gene expression
	are potentially key players in the integrated gene expression program involved in postnatal cardiac remodeling and maturation
	plays a role in genome maintenance or DNA-repair pathways
	augments cell survival after DNA damage from interstrand cross-linkers by facilitating nuclear import of FANCD2
	role of endogenous CEBPD in nuclear translocation of FANCD2
	CEBPD plays an essential role in HMDB (1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione)-mediated apoptosis of cancer cells
	necessary for efficient tumour metastasis
	enhances MTOR/AKT/S6K1 signalling and augments translation and activity of hypoxia-inducible factor-1á (HIF1A), which is necessary for hypoxia adaptation
	role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of Alzheimer disease pathogenesis

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	interacting with STAT3
	MYC, ZBTB17 and MAX are associated with the CEBPD promoter in proliferating cells, when CEBPD expression is repressed
	interacts with FANCD2 (CEBPD mediates the indirect association of FANCD2 with IPO4 through its interaction with both of these proteins via separate domains)
	inflammatory marker pentraxin-3 (PTX3) is a CEBPD target in astrocytes
	RRAD inhibits CTGF expression through binding with CEBPD, thus regulating ECM (extracellular matrix) production in the heart
	dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of CEBPB and CEBPD and direct transcriptional activation of PPARG2 and CEBPA during adipocyte differentiation

cell & other

REGULATION

repressed by

MYC, that represses CEBPD expression by associating with the CEBPD proximal promoter as a transient component of a repressive complex that includes MAX and ZBTB17

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   during heart development tumoral       loss of function in cervical cancer and hepatocellular carcinoma constitutional       gain of function in the astrocytes of Alzheimer patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     HMDB kills cancer cells through activation of CEBPD pathways and potentially can serve as a superior chemotherapeutic agent with limited potential for adverse side effects

ANIMAL & CELL MODELS