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FLASH GENE
Symbol PLAT contributors: mct - updated : 06-11-2015
HGNC name plasminogen activator, tissue
HGNC id 9051
Corresponding disease
PLAT thrombosis, recurrent
Location 8p11.21      Physical location : 42.032.235 - 42.065.194
Synonym name
  • plasminogen activator, tissue type
  • alteplase
  • reteplase
  • Synonym symbol(s) PLA, TPA
    EC.number 3.4.21.68
    DNA
    TYPE functioning gene
    STRUCTURE 33.01 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see RP1 RP1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3173 - 562 - 1996 8641693
    - - 2160 - 291 - 1996 8641693
    13 - 3035 - 516 - 1996 8641693
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly
    Reproductivefemale systemovary   
    Respiratorylung    
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    cysteine-rich kringle domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • serine protease activating the proenzyme plasminogen to plasmin, which in turn is responsible for fibrinolytic activity
  • implicated in neurite outgrowth and neurological recovery post stroke
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • while SERPINE1 and SERPINB2 function similarly in the control of cellular plasmin generation by PLAT, they may have disparate effects on the alternative functions of PLAT via modulation of its engagement with endocytosis receptors
  • PLAT-SERPINE1 system regulates the senescence-inducing activity of IGFBP3
  • IGFBP3 proteolysis by PLAT resulted in the inactivation of senescence-inducing activity of IGFBP3
  • PLAT influences spatial memory through its preferential interaction with GRIN2D subunit-containing NMDARs
  • binding of PLAT to VDAC1 induced a decrease in K(m) and an increase in the V(max) for activation of its substrate, plasminogen (Pg)
  • converts the zymogen plasminogen (PLG) into plasmin
  • interaction with S100P (S100P C-terminal lysine-dependent activation of tissue plasminogen activator (PLAT), but not of urokinase-catalysed plasminogen activation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAT
    Susceptibility to ischemic stroke
    Variant & Polymorphism other
  • -7351C/T polymorphism in PLAT would be a risk factor for ischemic stroke
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS