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FLASH GENE
Symbol PLAT contributors: mct - updated : 06-11-2013
HGNC name plasminogen activator, tissue
HGNC id 9051
Corresponding disease
PLAT thrombosis, recurrent
Location 8p11.21      Physical location : 42.032.235 - 42.065.194
Synonym name
  • plasminogen activator, tissue type
  • alteplase
  • reteplase
  • Synonym symbol(s) PLA, TPA
    EC.number 3.4.21.68
    DNA
    TYPE functioning gene
    STRUCTURE 33.01 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map see RP1 RP1
    Physical map
    C8orf4 8p11.2 chromosome 8 open reading frame 4 FLJ13842 8p11.21 hypothetical protein FLJ13842 SFRP1 8p12-p11.2 secreted frizzled-related protein 1 GCP16 LOC392214 8 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC14799 8p11.21 hypothetical protein MGC14799 DKFZp586M1819 8p11.21 putative lysophosphatidic acid acyltransferase FLJ25169 8p11.21 hypothetical protein FLJ25169 ANK1 8p11.2 ankyrin 1, erythrocytic MYST3 8p11 MYST histone acetyltransferase (monocytic leukemia) 3 AP3M2 8p11.2 adaptor-related protein complex 3, mu 2 subunit PLAT 8p12-p11.2 plasminogen activator, tissue LOC389650 8 LOC389650 IKBKB 8p11.2 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta POLB 8p11.2 polymerase (DNA directed), beta DKK4 8p11.2-p11.1 dickkopf homolog 4 (Xenopus laevis) VDAC3 8q11.2 voltage-dependent anion channel 3 SLC20A2 8p12-q21 solute carrier family 20 (phosphate transporter), member 2 LOC114926 8p11.21 hypothetical protein BC013035 CHRNB3 8p11.2 cholinergic receptor, nicotinic, beta polypeptide 3 CHRNA6 8p22 cholinergic receptor, nicotinic, alpha polypeptide 6 THAP1 8p11.1 THAP domain containing, apoptosis associated protein 1 DKFZP564A022 8p11.21 hypothetical protein DKFZp564A022 HOOK3 8p11.21 hook homolog 3 (Drosophila) FNTA 8p22-q11 farnesyltransferase, CAAX box, alpha FLJ23356 8p11.21 hypothetical protein FLJ23356 FLJ32731 8p11.1 hypothetical protein FLJ32731 LOC347028 8p11.21 similar to AFG3-like protein 2 (Paraplegin-like protein) LOC340441 8p11.21 similar to pote protein; Expressed in prostate, ovary, testis, and placenta LOC389651 8 similar to hypothetical protein (L1H 3 region) - human
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3173 - 562 - 1996 8641693
    - - 2160 - 291 - 1996 8641693
    13 - 3035 - 516 - 1996 8641693
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly
    Reproductivefemale systemovary   
    Respiratorylung    
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    cysteine-rich kringle domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • serine protease activating the proenzyme plasminogen to plasmin, which in turn is responsible for fibrinolytic activity
  • implicated in neurite outgrowth and neurological recovery post stroke
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • while SERPINE1 and SERPINB2 function similarly in the control of cellular plasmin generation by PLAT, they may have disparate effects on the alternative functions of PLAT via modulation of its engagement with endocytosis receptors
  • PLAT-SERPINE1 system regulates the senescence-inducing activity of IGFBP3
  • IGFBP3 proteolysis by PLAT resulted in the inactivation of senescence-inducing activity of IGFBP3
  • PLAT influences spatial memory through its preferential interaction with GRIN2D subunit-containing NMDARs
  • binding of PLAT to VDAC1 induced a decrease in K(m) and an increase in the V(max) for activation of its substrate, plasminogen (Pg)
  • converts the zymogen plasminogen (PLG) into plasmin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAT
    Susceptibility to ischemic stroke
    Variant & Polymorphism other
  • -7351C/T polymorphism in PLAT would be a risk factor for ischemic stroke
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS