| basic FUNCTION
| directly regulates microtubule dynamics at mitosis through phosphorylation of MAP4 ( |
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cdc2-mediated phosphorylation is an important regulator of nestin organization and dynamics during mitosis ( |
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acting as an histone 1-kinase (H1K) |
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involved in cell cycle regulation (G1 to S and G2 to M transition) |
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phosphorylating JUNB and lowering its level in mitotic and early G1 cells |
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putative upregulated c-Myc target gene |
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G2 phase CCNA1/CDK2 controls the timing of entry into mitosis by controlling the subsequent activation of CCNB/CDK1, but also has an unexpected role in coordinating the activation of CCNB/CDK1 at the centrosome and in the nucleus |
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is the only essential cell cycle CDK (in the absence of interphase Cdks, CDC2 can execute all the events that are required to drive cell division) |
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can activate CDC25C |
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phosphorylates ELAVL1 during G2, thereby helping to retain it in the nucleus in association with 14-3-3 and hindering its post-transcriptional function and anti-apoptotic influence |
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essential for DNA replication downstream formation of replication initiation complexes in hepatocytes but not in fibroblasts |
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involved in CDK1 and CDK2-mediated phosphorylation, a key mechanism governing EZH2 function |
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promote interphase nuclear pore complexes formation in human dividing cells |
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with AURKA and PLK1, participate in a feedback activation loop and activation of CDK1 initiates the feedback loop activity, leading to rapid and timely entry into mitosis |
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implicated in phosphorylation of CHEK1 which participates in cytoplasmic sequestration of CHEK1 activity |
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CDK1, CDK2, CDK5, can phosphorylate human DNMT1 at Ser154, suggesting an important role for CDKs in controlling DNA methylation patterns in mammalian cells |
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robust timing and ordering of cell cycle events depend on gradual changes in the substrate specificity of CDK1 |
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CDK1 and AURKB cooperatively modulate microtubule dynamics and AURKB-dependent phosphorylation of INCENP controls spindle function by excluding the CPC from spindle regions engaged in microtubule polymerization |
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permits resection by phosphorylation of RBBP8 but also prevents RAD51 binding to the resected ends during M-phase double-strand break repair |
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is a critical regulator of DSB repair in M phase |
