basic FUNCTION
| involved in Ig class switching |
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potentially involved in pathogenic cytokine production in inflammatory bone disease |
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IgE production in presence of IL-4 |
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playing a regulatory role in bone mineralization, in (regulating bone mass and in osteoclastogenesis |
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its expression on B cells prematurely terminated their ongoing germinal center response and produced plasma cells |
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costimulatory molecule expressed on T cells, and is also expressed and functional on platelets |
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platelet CD40LG plays a pivotal role in atherosclerosis, not only by affecting platelet-platelet interactions but especially by activating leukocytes, thereby increasing platelet-leukocyte and leukocyte-endothelium interactions |
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activation of CD40 by CD40LG plays a crucial role for the development and progression of a variety of inflammatory processes including atherosclerosis |
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is a thrombo-inflammatory molecule that predicts cardiovascular events |
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sCD40LG/CD40 axis triggers NFKB1 activation in platelets |
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soluble CD40LG is an important inducer of the NFKB1 signaling pathway activation in platelets independently of the MAPK14 pathway |
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IL21 and CD40LG collaborate through at least two distinct mechanisms to synergistically promote PRDM1 activation and plasma cells (PCs) differentiation |
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activation of CD40 on B cells, macrophages, and dendritic cells by its ligand CD40LG is essential for the development of humoral and cellular immune responses |
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may contribute directly to atherogenesis by activating endothelial cells and recruiting monocytes to them |
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soluble form of CD40LG(sCD40LG), which results from the shedding of membrane-bound CD40LG, plays a key role in the production of proinflammatory cytokines and has been linked to various autoimmune and vascular disorders |
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CD40-induced signalling through ligation with its natural ligand (CD40LG) is dependent on recruitment of TRAF molecules to the cytoplasmic domain of the receptor |
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role of sCD40LG in foam cell formation during atherosclerosis, which further confirms the importance of sCD40LG in atherosclerosis |