Citations for
1CD40, CD40LG, SPAG9
Scaffold protein JLP is critical for CD40 signaling in B lymphocytes.
Wang HM, Yan Q, Yang T, Cheng H, Du J, Yoshioka K, Kung SK, Ding GH.
J Biol Chem 290(9):5256-66. doi: 10.1074/jbc.M114.618496. Epub 2015 Jan 13. 2015
2CD40LG
Soluble CD40 ligand promotes macrophage foam cell formation in the etiology of atherosclerosis.
Yuan M, Fu H, Ren L, Wang H, Guo W.
Cardiology 131(1):1-12. doi: 10.1159/000374105. Epub 2015 Mar 24. 2015
3CD40LG
Soluble CD40 ligand promotes macrophage foam cell formation in the etiology of atherosclerosis.
Yuan M, Fu H, Ren L, Wang H, Guo W.
Cardiology 131(1):1-12. doi: 10.1159/000374105. Epub 2015 Mar 24. 2015
4CD40, CD40LG, FAF1
Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop.
Elmetwali T, Young LS, Palmer DH.
Cell Death Dis 5:e1213. doi: 10.1038/cddis.2014.172. 2014
5CD40LG, HIGM1
A novel mutation in the CD40 ligand gene in a Chinese boy with X-linked hyper-IgM syndrome.
Liu PN, Li H, Li Q, Yin ZW, Zhou CY, Jiang MY, Guo X.
Asian Pac J Allergy Immunol 32(3):270-4. doi: 10.12932/AP0365.32.3.2014. 2014
6CD40LG, MMP9, RAC1
Rac1 regulates platelet shedding of CD40L in abdominal sepsis.
Hwaiz R, Rahman M, Zhang E, Thorlacius H.
Lab Invest 94(9):1054-63. doi: 10.1038/labinvest.2014.92. Epub 2014 Jul 21. 2014
7CD40, CD40LG
CD154 is released from T-cells by a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and ADAM17 in a CD40 protein-dependent manner.
Yacoub D, Benslimane N, Al-Zoobi L, Hassan G, Nadiri A, Mourad W.
J Biol Chem 288(50):36083-93. doi: 10.1074/jbc.M113.506220. Epub 2013 Nov 4. 2013
8CD40, CD40LG
Cysteine-rich domain 1 of CD40 mediates receptor self-assembly.
Smulski CR, Beyrath J, Decossas M, Chekkat N, Wolff P, Estieu-Gionnet K, Guichard G, Speiser D, Schneider P, Fournel S.
J Biol Chem 288(15):10914-22. doi: 10.1074/jbc.M112.427583. Epub 2013 Mar 5. 2013
9CD40, CD40LG
Protein kinase C beta mediates CD40 ligand-induced adhesion of monocytes to endothelial cells.
Wu Z, Zhao G, Peng L, Du J, Wang S, Huang Y, Ou J, Jian Z.
PLoS One 8(9):e72593. doi: 10.1371/journal.pone.0072593. eCollection 2013. 2013
10CD40LG, IL21, PRDM1
IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
Ding BB, Bi E, Chen H, Yu JJ, Ye BH.
J Immunol 190(4):1827-36. doi: 10.4049/jimmunol.1201678. Epub 2013 Jan 16. 2013
11CD40, CD40LG, CHUK, NFKBIA
Involvement of nuclear factor κB in platelet CD40 signaling.
Hachem A, Yacoub D, Zaid Y, Mourad W, Merhi Y.
Biochem Biophys Res Commun 425(1):58-63. doi: 10.1016/j.bbrc.2012.07.049. Epub 2012 Jul 20. 2012
12CD40LG
Platelet-derived microparticles cause CD154-dependent activation of dendritic cells.
Nomura S, Fujita S, Nakanishi T, Yokoi T, Shimamoto K, Miyamoto R, Ito T.
Platelets 23(1):81-2. doi: 10.3109/09537104.2011.595850. No abstract available. 2012
13CD40, CD40LG, SELE
CD40/CD40L interaction induces E-selectin dependent leukocyte adhesion to human endothelial cells and inhibits endothelial cell migration.
Urban D, Thanabalasingam U, Stibenz D, Kaufmann J, Meyborg H, Fleck E, Gräfe M, Stawowy P.
Biochem Biophys Res Commun 404(1):448-52. Epub 2010 Dec 5. 2011
14CD40LG
Biomarkers for the diagnosis of prostatic inflammation in benign prostatic hyperplasia.
Robert G, Smit F, Hessels D, Jannink S, Karthaus HF, Aalders T, Jansen K, de la Taille A, Mulders PF, Schalken JA.
Prostate rostate. 2011 Mar 28. doi: 10.1002/pros.21387. [Epub ahead of print] 2011
15CD40LG, XIAP
Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG.
Rigaud S, Lopez-Granados E, Sibéril S, Gloire G, Lambert N, Lenoir C, Synaeve C, Stacey M, Fugger L, Stephan JL, Fischer A, Picard C, Durandy A, Chapel H, Latour S.
Blood 118(2):252-61. Epub 2011 May 4. 2011
16CD40, CD40LG
Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.
Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni PA, Shimoda M.
J Immunol 185(1):220-30. Epub 2010 May 26. Erratum in: J Immunol. 2010 Aug 15;185(4):2631. 2010
17CD40, CD40LG
The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease.
Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, van Kooten C, Lehnert H, Fellermann K, Büning J.
Am J Pathol 176(4):1816-27. Epub 2010 Feb 4. 2010
18CD40LG
Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.
Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix IC, Wijnands E, Goossens P, van Kruchten R, Thevissen L, Boon L, Flavell RA, Noelle RJ, Gerdes N, Biessen EA, Daemen MJ, Heemskerk JW, Weber C, Lutgens E.
Blood 116(20):4317-27. Epub 2010 Aug 12. 2010
19CD40, CD40LG, HIGM3
A novel mutation in CD40 and its functional characterization.
Qi CJ, Zheng L, Ma HB, Fei M, Qian KQ, Shen BR, Wu CP, Vihinen M, Zhang XG.
Hum Mutat 30(6):985-94. 2009
20CD40LG
Soluble CD40 ligand induces human coronary artery smooth muscle cells proliferation and migration.
Chai H, Aghaie K, Zhou W.
Surgery 146(1):5-11. Epub 2009 May 30. 2009
21CD40LG
The expression and concentration of CD40 ligand in normal pregnancy and pre-eclampsia.
Darmochwal-Kolarz D, Kolarz B, Surdacka A, Rolinski J, Leszczynska-Gorzelak B, Oleszczuk J.
J Reprod Immunol 79(2):215-9. Epub 2009 Feb 8. 2009
22CD40LG
Characterization of natural human antagonistic soluble CD40 isoforms produced through alternative splicing.
Eshel D, Toporik A, Efrati T, Nakav S, Chen A, Douvdevani A.
Mol Immunol 46(2):250-7. Epub 2008 Oct 11. 2008
23CD40LG
A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter.
Brunner M, Zhang M, Genin A, Ho IC, Cron RQ.
Genes Immun 9(7):640-9. Epub 2008 Aug 21. 2008
24CD40LG, HIGM1
Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis.
Lopez-Granados E, Temmerman ST, Wu L, Reynolds JC, Follmann D, Liu S, Nelson DL, Rauch F, Jain A.
Proc Natl Acad Sci U S A 104(12):5056-61. Epub 2007 Mar 9. 2007
25CD40LG, HIGM1
HIGM syndrome caused by insertion of an AluYb8 element in exon 1 of the CD40LG gene.
Apoil PA, Kuhlein E, Robert A, Rubie H, Blancher A.
Immunogenetics 59(1):17-23. Epub 2006 Dec 5. 2007
26CD40LG
Differential regulation of soluble and membrane CD40L proteins in T cells.
Matthies KM, Newman JL, Hodzic A, Wingett DG.
Cell Immunol 241(1):47-58. Epub 2006 Sep 11. 2006
27CD40LG
CD40 ligand gene and Kawasaki disease.
Onouchi Y, Onoue S, Tamari M, Wakui K, Fukushima Y, Yashiro M, Nakamura Y, Yanagawa H, Kishi F, Ouchi K, Terai M, Hamamoto K, Kudo F, Aotsuka H, Sato Y, Nariai A, Kaburagi Y, Miura M, Saji T, Kawasaki T, Nakamura Y, Hata A.
Eur J Hum Genet 12(12):1062-8. 2004
28EGR1, F3, CD40LG
Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1.
Bavendiek U, Libby P, Kilbride M, Reynolds R, Mackman N, Schonbeck U.
J Biol Chem 277(28):25032-9. 2002
29HIGM1, CD40LG
CD40 ligand expression deficiency in a female carrier of the X-linked hyper-IgM syndrome as a result of X chromosome lyonization.
de Saint Basile G, et al.
Eur J Immunol 29(1):367-73. 1999
30CD40LG, HIGM1, CD40
An aggressive form of polyarticular arthritis in a man with CD154 mutation (X-linked hyper-IgM syndrome).
Webster EA, et al.
Arthritis Rheum 42(6):1291-6. 1999
31CD40LG
Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production.
Liu Z, Colpaert S, D'Haens GR, Kasran A, de Boer M, Rutgeerts P, Geboes K, Ceuppens JL.
J Immunol 163(7):4049-57 1999
32CD40LG
Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.
Seyama K, et al.
Blood 92 : 2421-2434. 1998
33CD40LG, HIGM1
Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome.
Nonoyama S, Shimadzu M, Toru H, Seyama K, Nunoi H, Neubauer M, Yata J, Och HD.
Hum Genet 99(5):624-7. 1997
34CD40LG, HIGM1
A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome.
Lin Q, et al.
J Clin Invest 97 : 196-201. 1996
35CD40LG, HIGM1
Genomic structure and PCR-SSCP analysis of the human CD40 ligand gene : its application to prenatal screening for X-linked hyper-IgM syndrome.
Seyama K, et al.
Hum Genet 97 : 180-185. 1996
36CD40LG, HIGM1
A novel splice-site mutation in the CD40L gene in a patient with X-linked hyper-IgM syndrome.
Dezso D, et al.
Hum Mutat 7 : 181. 1996
37CD40LG, HIGM1
Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome.
Katz F, et al.
Hum Mutat 8 : 223-228. 1996
38ADFN, CD40LG, F9, GPC3, HPRT1, HPT1, HTX1, MCF2, THAS
YAC/STS map of 9 Mb of Xq26 at 100-kb resolution, localizing 6 ESTs, 6 genes, and 32 genetic markers.
Pilia G, et al.
Genomics 34 : 55-62. 1996
39CD40LG, TRAF5
TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.
Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J.
Proc Natl Acad Sci U S A 93(18):9437-42. 1996
40CD40LG, HIGM1
A point mutation in exon 2 of the CD40 ligand gene causes the simultaneous expression of two defective mRNA species in X-linked hyperimmunoglobulinemia M.
Ramesh N, et al.
Hum Mol Genet 4 : 759-761. 1995
41HIGM1, CD40LG
Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry.
Macchi P, et al.
Am J Hum Genet 56 : 898-906. 1995
42CD40LG
Structural organization of the gene for CD40 ligand : molecular analysis for diagnosis of X-linked hyper-IgM syndrome.
Shimadzu M, et al.
Biochim Biophys Acta 1260 : 67-72. 1995
43CD40LG, HIGM1
C to T mutation causing premature termination of CD40 ligand at amino acid 221 in a patient affected by hyper IgM syndrome.
Villa A, et al.
Hum Mutat 3 : 73-75. 1994
44CD40LG, HIGM1
Organization of the human CD40L gene : implications for molecular defects in X chromosome-linked hyper-IgM syndrome and prenatal diagnosis.
Villa A, et al.
Proc Natl Acad Sci U S A 91 : 2110-2114. 1994
45CD40LG
Human CD40L gene maps between DXS144E and DXS300 in Xq26.
Pilia G, et al.
Genomics 22 : 249-251. 1994
46HIGM1, CD40LG
The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome in female carriers of HIGM1.
Hollenbaugh D, et al.
J Clin Invest 94 : 616-622. 1994
47CD40LG
Dinucleotide repeat polymorphism in the human CD40 ligand gene.
Allen RC, et al.
Hum Mol Genet 2 : 828. 1993
48CD40LG
CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome.
Allen RC, et al.
Science 259 : 990-993. 1993
49CD40LG
CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM.
DiSanto JP, et al.
Nature 361 : 541-543. 1993
50CD40LG
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM.
KorthŠuer U, et al.
Nature 361 : 539-541. 1993
51CD40LG
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
Aruffo A, et al.
Cell 72 : 291-300. 1993
52CD40LG
Cloning of TRAP, a ligand for CD40 on human T cells.
Graf D, et al.
Eur J Immunol 22 : 3191-3194. 1992