1 | CD40, CD40LG, SPAG9
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| Scaffold protein JLP is critical for CD40 signaling in B lymphocytes.
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| Wang HM, Yan Q, Yang T, Cheng H, Du J, Yoshioka K, Kung SK, Ding GH.
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| J Biol Chem 290(9):5256-66. doi: 10.1074/jbc.M114.618496. Epub 2015 Jan 13.
2015
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2 | CD40LG
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| Soluble CD40 ligand promotes macrophage foam cell formation in the etiology of atherosclerosis.
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| Yuan M, Fu H, Ren L, Wang H, Guo W.
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| Cardiology 131(1):1-12. doi: 10.1159/000374105. Epub 2015 Mar 24.
2015
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3 | CD40LG
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| Soluble CD40 ligand promotes macrophage foam cell formation in the etiology of atherosclerosis.
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| Yuan M, Fu H, Ren L, Wang H, Guo W.
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| Cardiology 131(1):1-12. doi: 10.1159/000374105. Epub 2015 Mar 24.
2015
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4 | CD40, CD40LG, FAF1
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| Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop.
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| Elmetwali T, Young LS, Palmer DH.
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| Cell Death Dis 5:e1213. doi: 10.1038/cddis.2014.172.
2014
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5 | CD40LG, HIGM1
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| A novel mutation in the CD40 ligand gene in a Chinese boy with X-linked hyper-IgM syndrome.
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| Liu PN, Li H, Li Q, Yin ZW, Zhou CY, Jiang MY, Guo X.
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| Asian Pac J Allergy Immunol 32(3):270-4. doi: 10.12932/AP0365.32.3.2014.
2014
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6 | CD40LG, MMP9, RAC1
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| Rac1 regulates platelet shedding of CD40L in abdominal sepsis.
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| Hwaiz R, Rahman M, Zhang E, Thorlacius H.
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| Lab Invest 94(9):1054-63. doi: 10.1038/labinvest.2014.92. Epub 2014 Jul 21.
2014
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7 | CD40, CD40LG
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| CD154 is released from T-cells by a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) and ADAM17 in a CD40 protein-dependent manner.
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| Yacoub D, Benslimane N, Al-Zoobi L, Hassan G, Nadiri A, Mourad W.
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| J Biol Chem 288(50):36083-93. doi: 10.1074/jbc.M113.506220. Epub 2013 Nov 4.
2013
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8 | CD40, CD40LG
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| Cysteine-rich domain 1 of CD40 mediates receptor self-assembly.
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| Smulski CR, Beyrath J, Decossas M, Chekkat N, Wolff P, Estieu-Gionnet K, Guichard G, Speiser D, Schneider P, Fournel S.
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| J Biol Chem 288(15):10914-22. doi: 10.1074/jbc.M112.427583. Epub 2013 Mar 5.
2013
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9 | CD40, CD40LG
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| Protein kinase C beta mediates CD40 ligand-induced adhesion of monocytes to endothelial cells.
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| Wu Z, Zhao G, Peng L, Du J, Wang S, Huang Y, Ou J, Jian Z.
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| PLoS One 8(9):e72593. doi: 10.1371/journal.pone.0072593. eCollection 2013.
2013
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10 | CD40LG, IL21, PRDM1
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| IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
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| Ding BB, Bi E, Chen H, Yu JJ, Ye BH.
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| J Immunol 190(4):1827-36. doi: 10.4049/jimmunol.1201678. Epub 2013 Jan 16.
2013
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11 | CD40, CD40LG, CHUK, NFKBIA
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| Involvement of nuclear factor κB in platelet CD40 signaling.
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| Hachem A, Yacoub D, Zaid Y, Mourad W, Merhi Y.
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| Biochem Biophys Res Commun 425(1):58-63. doi: 10.1016/j.bbrc.2012.07.049. Epub 2012 Jul 20.
2012
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12 | CD40LG
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| Platelet-derived microparticles cause CD154-dependent activation of dendritic cells.
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| Nomura S, Fujita S, Nakanishi T, Yokoi T, Shimamoto K, Miyamoto R, Ito T.
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| Platelets 23(1):81-2. doi: 10.3109/09537104.2011.595850. No abstract available.
2012
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13 | CD40, CD40LG, SELE
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| CD40/CD40L interaction induces E-selectin dependent leukocyte adhesion to human endothelial cells and inhibits endothelial cell migration.
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| Urban D, Thanabalasingam U, Stibenz D, Kaufmann J, Meyborg H, Fleck E, Gräfe M, Stawowy P.
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| Biochem Biophys Res Commun 404(1):448-52. Epub 2010 Dec 5. 2011
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14 | CD40LG
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| Biomarkers for the diagnosis of prostatic inflammation in benign prostatic hyperplasia.
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| Robert G, Smit F, Hessels D, Jannink S, Karthaus HF, Aalders T, Jansen K, de la Taille A, Mulders PF, Schalken JA.
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| Prostate rostate. 2011 Mar 28. doi: 10.1002/pros.21387. [Epub ahead of print]
2011
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15 | CD40LG, XIAP
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| Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG.
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| Rigaud S, Lopez-Granados E, Sibéril S, Gloire G, Lambert N, Lenoir C, Synaeve C, Stacey M, Fugger L, Stephan JL, Fischer A, Picard C, Durandy A, Chapel H, Latour S.
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| Blood 118(2):252-61. Epub 2011 May 4.
2011
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16 | CD40, CD40LG
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| Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.
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| Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni PA, Shimoda M.
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| J Immunol 185(1):220-30. Epub 2010 May 26. Erratum in: J Immunol. 2010 Aug 15;185(4):2631.
2010
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17 | CD40, CD40LG
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| The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease.
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| Borcherding F, Nitschke M, Hundorfean G, Rupp J, von Smolinski D, Bieber K, van Kooten C, Lehnert H, Fellermann K, Büning J.
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| Am J Pathol 176(4):1816-27. Epub 2010 Feb 4.
2010
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18 | CD40LG
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| Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.
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| Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix IC, Wijnands E, Goossens P, van Kruchten R, Thevissen L, Boon L, Flavell RA, Noelle RJ, Gerdes N, Biessen EA, Daemen MJ, Heemskerk JW, Weber C, Lutgens E.
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| Blood 116(20):4317-27. Epub 2010 Aug 12.
2010
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19 | CD40, CD40LG, HIGM3
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| A novel mutation in CD40 and its functional characterization.
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| Qi CJ, Zheng L, Ma HB, Fei M, Qian KQ, Shen BR, Wu CP, Vihinen M, Zhang XG.
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| Hum Mutat 30(6):985-94. 2009
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20 | CD40LG
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| Soluble CD40 ligand induces human coronary artery smooth muscle cells proliferation and migration.
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| Chai H, Aghaie K, Zhou W.
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| Surgery 146(1):5-11. Epub 2009 May 30.
2009
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21 | CD40LG
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| The expression and concentration of CD40 ligand in normal pregnancy and pre-eclampsia.
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| Darmochwal-Kolarz D, Kolarz B, Surdacka A, Rolinski J, Leszczynska-Gorzelak B, Oleszczuk J.
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| J Reprod Immunol 79(2):215-9. Epub 2009 Feb 8.
2009
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22 | CD40LG
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| Characterization of natural human antagonistic soluble CD40 isoforms produced through alternative splicing.
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| Eshel D, Toporik A, Efrati T, Nakav S, Chen A, Douvdevani A.
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| Mol Immunol 46(2):250-7. Epub 2008 Oct 11.
2008
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23 | CD40LG
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| A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter.
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| Brunner M, Zhang M, Genin A, Ho IC, Cron RQ.
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| Genes Immun 9(7):640-9. Epub 2008 Aug 21.
2008
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24 | CD40LG, HIGM1
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| Osteopenia in X-linked hyper-IgM syndrome reveals a regulatory role for CD40 ligand in osteoclastogenesis.
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| Lopez-Granados E, Temmerman ST, Wu L, Reynolds JC, Follmann D, Liu S, Nelson DL, Rauch F, Jain A.
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| Proc Natl Acad Sci U S A 104(12):5056-61. Epub 2007 Mar 9. 2007
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25 | CD40LG, HIGM1
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| HIGM syndrome caused by insertion of an AluYb8 element in exon 1 of the CD40LG gene.
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| Apoil PA, Kuhlein E, Robert A, Rubie H, Blancher A.
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| Immunogenetics 59(1):17-23. Epub 2006 Dec 5.
2007
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26 | CD40LG
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| Differential regulation of soluble and membrane CD40L proteins in T cells.
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| Matthies KM, Newman JL, Hodzic A, Wingett DG.
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| Cell Immunol 241(1):47-58. Epub 2006 Sep 11. 2006
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27 | CD40LG
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| CD40 ligand gene and Kawasaki disease.
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| Onouchi Y, Onoue S, Tamari M, Wakui K, Fukushima Y, Yashiro M, Nakamura Y, Yanagawa H, Kishi F, Ouchi K, Terai M, Hamamoto K, Kudo F, Aotsuka H, Sato Y, Nariai A, Kaburagi Y, Miura M, Saji T, Kawasaki T, Nakamura Y, Hata A.
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| Eur J Hum Genet 12(12):1062-8. 2004
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28 | EGR1, F3, CD40LG
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| Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1.
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| Bavendiek U, Libby P, Kilbride M, Reynolds R, Mackman N, Schonbeck U.
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| J Biol Chem 277(28):25032-9. 2002
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29 | HIGM1, CD40LG
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| CD40 ligand expression deficiency in a female carrier of the X-linked hyper-IgM syndrome as a result of X chromosome lyonization.
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| de Saint Basile G, et al.
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| Eur J Immunol 29(1):367-73. 1999
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30 | CD40LG, HIGM1, CD40
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| An aggressive form of polyarticular arthritis in a man with CD154 mutation (X-linked hyper-IgM syndrome).
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| Webster EA, et al.
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| Arthritis Rheum 42(6):1291-6. 1999
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31 | CD40LG
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| Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production.
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| Liu Z, Colpaert S, D'Haens GR, Kasran A, de Boer M, Rutgeerts P, Geboes K, Ceuppens JL.
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| J Immunol 163(7):4049-57 1999
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32 | CD40LG
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| Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.
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| Seyama K, et al.
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| Blood 92 : 2421-2434. 1998
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33 | CD40LG, HIGM1
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| Mutations of the CD40 ligand gene in 13 Japanese patients with X-linked hyper-IgM syndrome.
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| Nonoyama S, Shimadzu M, Toru H, Seyama K, Nunoi H, Neubauer M, Yata J, Och HD.
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| Hum Genet 99(5):624-7. 1997
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34 | CD40LG, HIGM1
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| A single strand conformation polymorphism study of CD40 ligand. Efficient mutation analysis and carrier detection for X-linked hyper IgM syndrome.
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| Lin Q, et al.
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| J Clin Invest 97 : 196-201. 1996
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35 | CD40LG, HIGM1
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| Genomic structure and PCR-SSCP analysis of the human CD40 ligand gene : its application to prenatal screening for X-linked hyper-IgM syndrome.
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| Seyama K, et al.
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| Hum Genet 97 : 180-185. 1996
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36 | CD40LG, HIGM1
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| A novel splice-site mutation in the CD40L gene in a patient with X-linked hyper-IgM syndrome.
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| Dezso D, et al.
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| Hum Mutat 7 : 181. 1996
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37 | CD40LG, HIGM1
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| Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome.
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| Katz F, et al.
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| Hum Mutat 8 : 223-228. 1996
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38 | ADFN, CD40LG, F9, GPC3, HPRT1, HPT1, HTX1, MCF2, THAS
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| YAC/STS map of 9 Mb of Xq26 at 100-kb resolution, localizing 6 ESTs, 6 genes, and 32 genetic markers.
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| Pilia G, et al.
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| Genomics 34 : 55-62. 1996
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39 | CD40LG, TRAF5
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| TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.
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| Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J.
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| Proc Natl Acad Sci U S A 93(18):9437-42. 1996
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40 | CD40LG, HIGM1
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| A point mutation in exon 2 of the CD40 ligand gene causes the simultaneous expression of two defective mRNA species in X-linked hyperimmunoglobulinemia M.
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| Ramesh N, et al.
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| Hum Mol Genet 4 : 759-761. 1995
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41 | HIGM1, CD40LG
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| Characterization of nine novel mutations in the CD40 ligand gene in patients with X-linked hyper IgM syndrome of various ancestry.
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| Macchi P, et al.
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| Am J Hum Genet 56 : 898-906. 1995
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42 | CD40LG
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| Structural organization of the gene for CD40 ligand : molecular analysis for diagnosis of X-linked hyper-IgM syndrome.
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| Shimadzu M, et al.
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| Biochim Biophys Acta 1260 : 67-72. 1995
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43 | CD40LG, HIGM1
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| C to T mutation causing premature termination of CD40 ligand at amino acid 221 in a patient affected by hyper IgM syndrome.
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| Villa A, et al.
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| Hum Mutat 3 : 73-75. 1994
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44 | CD40LG, HIGM1
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| Organization of the human CD40L gene : implications for molecular defects in X chromosome-linked hyper-IgM syndrome and prenatal diagnosis.
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| Villa A, et al.
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| Proc Natl Acad Sci U S A 91 : 2110-2114. 1994
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45 | CD40LG
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| Human CD40L gene maps between DXS144E and DXS300 in Xq26.
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| Pilia G, et al.
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| Genomics 22 : 249-251. 1994
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46 | HIGM1, CD40LG
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| The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome in female carriers of HIGM1.
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| Hollenbaugh D, et al.
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| J Clin Invest 94 : 616-622. 1994
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47 | CD40LG
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| Dinucleotide repeat polymorphism in the human CD40 ligand gene.
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| Allen RC, et al.
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| Hum Mol Genet 2 : 828. 1993
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48 | CD40LG
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| CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome.
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| Allen RC, et al.
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| Science 259 : 990-993. 1993
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49 | CD40LG
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| CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM.
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| DiSanto JP, et al.
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| Nature 361 : 541-543. 1993
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50 | CD40LG
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| Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM.
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| KorthŠuer U, et al.
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| Nature 361 : 539-541. 1993
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51 | CD40LG
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| The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
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| Aruffo A, et al.
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| Cell 72 : 291-300. 1993
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52 | CD40LG
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| Cloning of TRAP, a ligand for CD40 on human T cells.
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| Graf D, et al.
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| Eur J Immunol 22 : 3191-3194. 1992
|