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FLASH GENE
Symbol CCT5 contributors: mct/npt - updated : 19-05-2010
HGNC name chaperonin containing TCP1, subunit 5 (epsilon)
HGNC id 1618
Corresponding disease
SNSP sensory neuropathy with spastic paraplegia
Location 5p15.2      Physical location : 10.250.281 - 10.266.500
Synonym name T-complex protein 1, epsilon subunit
Synonym symbol(s) CCT-epsilon, CCTE, KIAA0098, TCP-1-epsilon
DNA
TYPE functioning gene
STRUCTURE 16.22 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D5S630 - CCT5 - D5S478 - cen
Authors Gene Map (98)
Physical map
LOC391735 5 similar to hypothetical protein FLJ36144 ADCY2 5p15.33-p15.31 adenylate cyclase 2 (brain) MGC5297 5p15.3-p15.2 hypothetical protein MGC5297 MTRR 5p15.31 5-methyltetrahydrofolate-homocysteine methyltransferase reductase SEMA5A 5p15-pter sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A TAS2R1 5p15.2 taste receptor, type 2, member 1 LOC389271 5 LOC389271 LOC134145 5p15.31 hypothetical protein LOC134145 CCT5 5p15.2 chaperonin containing TCP1, subunit 5 (epsilon) LOC134147 5p15.31 hypothetical protein BC001573 TEB4 5p15.2 similar to S. cerevisiae SSM4 ASP 5p15.31 AKAP-associated sperm protein LOC389272 5 LOC389272 LOC389273 5 hypothetical gene supported by AK130861 LOC391736 5 similar to S-antigen precursor - malaria parasite (Plasmodium falciparum) (strain V1/Vietnam) LOC345711 5p15.31 similar to RIKEN cDNA 0610012A05 LOC391737 5 similar to Intersectin 1 (SH3 domain-containing protein 1A) (SH3P17) DAP 5p12.2 death-associated protein CTNND2 5p15.3 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) LOC389274 5 LOC389274
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3403 - 541 - Roobol (1995)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer
HOMOLOGY
Homologene
FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • assembled into a TCP1-ring complex (TRIC) and mediating ATP-dependent monomeric protein folding
  • cytosolic molecular chaperone implicated especially in the biogenesis of cytoskeletal proteins by promoting the correct folding of the major ubiquitous cytoskeletal components, tubulin and actin (Roobol 1995)
  • may be playing a role, in the folding of actin and tubulin
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex (970kDa)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PACRG
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SNSP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS