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FLASH GENE

Symbol

CARD10

contributors: mct/npt/pgu - updated : 16-04-2013

HGNC name	caspase recruitment domain family, member 10
HGNC id	16422

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.1      Physical location : 37.886.400 - 37.915.210
Synonym name	CARD-containing MAGUK 3 protein
	Bcl10 binding protein and activator of NFKB
	carma 3
Synonym symbol(s)	CARMA3, BIMP1, MGC142219

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	28.81 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014550 20 - 3912 NP_055365 - 1032 - 2008 18349075

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Reproductive male system testis     highly Respiratory respiratory tract       specific Homo sapiens Adult Urinary kidney       highly

cells

System Cell Pubmed Species Stage Rna symbol Respiratory epithelial cell Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

puberty

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a caspase recruitment domain(CARD)
	a membrane-associated guanylate kinase-like domain (MAGUK) domain

HOMOLOGY

Homologene

FAMILY

MAGUK and CARD protein families

CATEGORY

chaperone/stress , regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	inducer of BCL10 phosphrylation and NF-kappa B activation
	may function as a molecular scaffold for the assembly of BCL10 signaling complex
	required for GPCR-induced NF-kappaB activation
	mediate NF-kappaB activation in embryonic fibroblasts after stimulation with lysophosphatidic acid (LPA), a bioactive lipid-mediator that is elevated in the lungs of individuals with asthma
	mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells
	required for EGF-induced NFKB activation
	CARD10 and BCL10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signaling pathway mediating Angiotensin II-dependent activation of NF-B, which is composed of three principal proteins, CARMA3, BCL10, and MALT1

a component	of a ternary complex with BCL10 and MALT1
	CARD10-BCL10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis

INTERACTION

DNA

RNA

small molecule

protein	BCL10
	protein kinase C
	CARD11 and CARD10 physically associate with Ikappa kinase gamma/NFkappaB essential modulator (IkappaKgamma-NEMO) in lymphoid and non-lymphoid cells
	associated with NEMO/IKBKG, and induces polyubiquitination of an unknown protein(s) that associates with IKBKG, likely by linking IKBKG to TRAF6

cell & other

REGULATION

inhibited by

TNFAIP3 (negative regulator of BCL10- and CARD10-mediated activation of NFkappaB)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NFKB mediated upregulation of CCND1

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   could serve as a potential companion drug target, along with NFKB and EGFR in EGFR-mutant lung cancers

ANIMAL & CELL MODELS