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FLASH GENE
Symbol CARD10 contributors: mct/npt/pgu - updated : 16-04-2013
HGNC name caspase recruitment domain family, member 10
HGNC id 16422
Location 22q13.1      Physical location : 37.886.400 - 37.915.210
Synonym name
  • CARD-containing MAGUK 3 protein
  • Bcl10 binding protein and activator of NFKB
  • carma 3
  • Synonym symbol(s) CARMA3, BIMP1, MGC142219
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 28.81 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MPST 22q13.1 mercaptopyruvate sulfurtransferase FLJ12242 22q13.1 hypothetical protein FLJ12242 TMPRSS6 22q13.1 transmembrane serine protease 6 IL2RB 22q13.1 interleukin 2 receptor, beta C1QTNF6 22q13.1 C1q and tumor necrosis factor related protein 6 SSTR3 22q13.1 somatostatin receptor 3 RAC2 22q13.1 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) PSCD4 22q13.1 pleckstrin homology, Sec7 and coiled-coil domains 4 KIAA1904 22q13.1 KIAA1904 protein MFNG 22q13.1 manic fringe homolog (Drosophila) CARD10 22q13 caspase recruitment domain family, member 10 CDC42EP1 22q13.1 CDC42 effector protein (Rho GTPase binding) 1 LGALS2 22q13.1 lectin, galactoside-binding, soluble, 2 (galectin 2) GGA1 22q13.31 golgi associated, gamma adaptin ear containing, ARF binding protein 1 SH3BP1 22q13.1 SH3-domain binding protein 1 PLP LGALS1 22q13.1 lectin, galactoside-binding, soluble, 1 (galectin 1) MGC3731 22q13.1 hypothetical protein MGC3731 HRIHFB2122 22q13.1 hypothetical protein MGC3731 H1F0 22q13.1 H1 histone family, member 0 GCAT 22q13.1 glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) GALR3 22q13.1 galanin receptor 3 LOC129138 22q13.1 hypothetical protein BC014641 EIF3S6IP 22q12-q13 eukaryotic translation initiation factor 3, subunit 6 interacting protein MIRAB13 22q13.1-q13.2 molecule interacting with Rab13
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3912 - 1032 - 2008 18349075
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tract   specific Homo sapiensAdult
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Respiratoryepithelial cell Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period puberty
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a caspase recruitment domain(CARD)
  • a membrane-associated guanylate kinase-like domain (MAGUK) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • MAGUK and CARD protein families
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducer of BCL10 phosphrylation and NF-kappa B activation
  • may function as a molecular scaffold for the assembly of BCL10 signaling complex
  • required for GPCR-induced NF-kappaB activation
  • mediate NF-kappaB activation in embryonic fibroblasts after stimulation with lysophosphatidic acid (LPA), a bioactive lipid-mediator that is elevated in the lungs of individuals with asthma
  • mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells
  • required for EGF-induced NFKB activation
  • CARD10 and BCL10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    signaling pathway mediating Angiotensin II-dependent activation of NF-B, which is composed of three principal proteins, CARMA3, BCL10, and MALT1
    a component
  • of a ternary complex with BCL10 and MALT1
  • CARD10-BCL10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL10
  • protein kinase C
  • CARD11 and CARD10 physically associate with Ikappa kinase gamma/NFkappaB essential modulator (IkappaKgamma-NEMO) in lymphoid and non-lymphoid cells
  • associated with NEMO/IKBKG, and induces polyubiquitination of an unknown protein(s) that associates with IKBKG, likely by linking IKBKG to TRAF6
  • cell & other
    REGULATION
    inhibited by TNFAIP3 (negative regulator of BCL10- and CARD10-mediated activation of NFkappaB)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NFKB mediated upregulation of CCND1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    could serve as a potential companion drug target, along with NFKB and EGFR in EGFR-mutant lung cancers
    ANIMAL & CELL MODELS