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FLASH GENE
Symbol CARD10 contributors: mct/npt/pgu - updated : 16-04-2013
HGNC name caspase recruitment domain family, member 10
HGNC id 16422
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a caspase recruitment domain(CARD)
  • a membrane-associated guanylate kinase-like domain (MAGUK) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • MAGUK and CARD protein families
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducer of BCL10 phosphrylation and NF-kappa B activation
  • may function as a molecular scaffold for the assembly of BCL10 signaling complex
  • required for GPCR-induced NF-kappaB activation
  • mediate NF-kappaB activation in embryonic fibroblasts after stimulation with lysophosphatidic acid (LPA), a bioactive lipid-mediator that is elevated in the lungs of individuals with asthma
  • mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells
  • required for EGF-induced NFKB activation
  • CARD10 and BCL10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    signaling pathway mediating Angiotensin II-dependent activation of NF-B, which is composed of three principal proteins, CARMA3, BCL10, and MALT1
    a component
  • of a ternary complex with BCL10 and MALT1
  • CARD10-BCL10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL10
  • protein kinase C
  • CARD11 and CARD10 physically associate with Ikappa kinase gamma/NFkappaB essential modulator (IkappaKgamma-NEMO) in lymphoid and non-lymphoid cells
  • associated with NEMO/IKBKG, and induces polyubiquitination of an unknown protein(s) that associates with IKBKG, likely by linking IKBKG to TRAF6
  • cell & other
    REGULATION
    inhibited by TNFAIP3 (negative regulator of BCL10- and CARD10-mediated activation of NFkappaB)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NFKB mediated upregulation of CCND1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    could serve as a potential companion drug target, along with NFKB and EGFR in EGFR-mutant lung cancers
    ANIMAL & CELL MODELS