basic FUNCTION
| inducer of BCL10 phosphrylation and NF-kappa B activation |
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may function as a molecular scaffold for the assembly of BCL10 signaling complex |
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required for GPCR-induced NF-kappaB activation |
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mediate NF-kappaB activation in embryonic fibroblasts after stimulation with lysophosphatidic acid (LPA), a bioactive lipid-mediator that is elevated in the lungs of individuals with asthma |
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mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells |
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required for EGF-induced NFKB activation |
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CARD10 and BCL10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion |