protein
| importin-alpha subunit of the nuclear transport signal receptor |
|
Rad51 |
|
p32 and p65 BRCA1 interacting proteins, cyclin A, cyclin B1, cyclin D1, cdc2, cdk2 and E2F |
|
BRAP2 |
|
BAP1 |
|
p53 |
|
a component of the RNA polymerase II (Pol II) holoenzyme |
|
BRCA2 |
|
c-Myc |
|
CtIP |
|
gamma-tubulin |
|
CtBP |
|
RbAp46 and RbAp48, HDAC1 and HDAC2 |
|
hRad50-hMre11-p95 complex |
|
hypophosphorylated form of pRb |
|
CBP/p300 |
|
BRCA1-associated genome surveillance complex: MSH2, MSH6, MLH1, ATM, BLM, and the RAD50-MRE11-NBS1 protein complex, and DNA replication factor C, RFC |
|
RNA polymerase II |
|
STAT1 |
|
valosin-containing protein, VCP |
|
ZBRK1 |
|
ATF1 |
|
androgen receptor, AR and p160 |
|
checkpoint kinase ATR |
|
JAK1 and JAK2 |
|
FANCD2 |
|
BACH1 |
|
retinoblastoma suppressor (Rb)-associated protein 46, RbAp46 |
|
c-Fos oncogene regulator Elk-1 |
|
LMO4 |
|
GADD45 |
|
N-Myc-interacting protein, Nmi |
|
c-Abl |
|
JUNB and JUND |
|
alpha- and beta-tubulin |
|
Fanconi anemia protein, FANCA |
|
Acetyl Coenzyme A (CoA) Carboxylase alpha, ACCA |
|
ER-alpha |
|
Stat5a |
|
phosphatase 1alpha, PP1alpha |
|
Sp1 |
|
p65/RelA |
|
four and a half LIM-only protein 2, FHL2 |
|
BARD1/BRCC45/BRCC36 |
|
IFI16 |
|
p53 |
|
Aurora-A |
|
FHL2 |
|
zinc-finger-containing protein NUFIP |
|
nucleolar phosphoprotein nucleophosmin/B23, NPM |
|
SWI/SNF enzymes |
|
mitogen-activated protein kinase (MAPK) kinase kinase 3, MEKK3 |
|
TRAP220 |
|
Cdk-activating kinase, CAK |
|
Smad3 |
|
hGCN5, TRRAP, and hMSH2/6 |
|
poly(A)-binding protein 1, PABP |
|
cyclin D1 |
|
Abraxas and RAP80 |
|
TR-interacting protein, ATRIP |
|
CCDC98 |
|
aryl hydrocarbon receptor, AhR |
|
ERK1/2 |
|
p14ARF |
|
Ku80 |
|
vitamin D receptor, VDR |
|
Rap80 |
|
NBA1 |
|
Mediator of Rap80 Interactions and Targeting 40 kd, MERIT40 |
|
PALB2 |
|
NINL ( |
|
centrosomal protein Nlp |
|
E2s |
|
deleted in breast cancer 1, DBC1/KIAA1967 |
|
FANCJ |
|
BRD7 |
|
MRG15 |
|
UBXN1 |
|
HERC2 |
|
UE2I |
|
TFII-I |
|
BCL2 |
|
KIAA0101 |
|
YY1 binds to the promoter of BRCA1, and its overexpression resulted in increased expression of BRCA1 and a number of BRCA1 downstream genes |
|
Cockayne syndrome B, CSB |
|
BARD1 |
|
AP2-alpha, PAX2 and ZF5 |
|
CDK1 |
|
interaction between the breast/ovarian tumor suppressor gene BRCA1 and the transcription factor GATA3, an interaction, which is important for normal breast differentiation |
|
gamma tubulin, CRM1, and Aurora A |
|
BRCA1 antagonises TP53BP1-dependent DNA repair in S phase by inhibiting its interaction with chromatin proximal to damage sites |
|
claspin ( |
|
loss of HSP90AA1 function abolishes BRCA1-dependent DSB repair |
|
SKP1 regulates BRCA1 protein stability |
|
FBXO44 is an important protein that influences BRCA1 protein level |
|
BRCA1 heterodimerizes with its partner protein, BARD1, via the RING domain present in both proteins |
|
BRCA1-dependent degradation of cyclin B and CDC25C is reversed by proteasome inhibitors and is enhanced following DNA damage, which may represent a possible mechanism to prevent cyclin B and CDC25C accumulation, a requirement for mitotic entry |
|
RBBP8 interacts with NBN and BRCA1, and connects CDK and ATM to regulate homologous recombination (HR)-mediated double-strand break repair |
|
ZNF423 appeared to be an estrogen-inducible BRCA1 transcription factor |
|
DCLRE1B is a nuclease required for efficient localization of the DNA repair proteins, FANCD2 and BRCA1 |
|
BRCA1 downregulates the kinase activity of PLK1 by modulating the dynamic interactions of AURKA, BORA, and PLK1 |
|
TP53BP1 recruitment requires the direct recognition of a DSB-specific histone code and its influence on pathway choice is mediated by mutual antagonism with BRCA1 |
|
KDM5B is required for efficient DSB repair and for the recruitment of XRCC6 and BRCA1, the essential component of nonhomologous end-joining and homologous recombination, respectively |
|
FAM175A is a BRCA1 BRCT domain-interacting protein, playing a role in tumor suppression |
|
BRCA1 and BLM interact with RAD50 predominantly in S- and G2-phases, respectively |
|
functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer |
|
BRCA1 and BRIP1 cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of PLK1 |
|
gain of function mutant TP53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression |
|
CEP72 is a novel BRCA1-interacting protein |
|
high levels of CEP72 counteract CHEK2 as a positive regulator of BRCA1 to ensure proper mitotic microtubule assembly |
|
BABAM1 is an essential component of the RAP80 ubiquitin recognition complex that targets BRCA1 to DNA damage sites |
|
mitotic function of BRCA1 depends on its phosphorylation by the tumor-suppressor kinase CHEK2 and this regulation is required to ensure normal microtubule plus end assembly rates within mitotic spindles |
|
dual molecular mechanism by which the CHEK2-BRCA1 axis restrains oncogenic AURKA activity during mitosis and BRCA1 itself is a target for AURKA relevant for chromosomal instability (CIN) |
|
ERCC5 is a partner of BRCA1 and BRCA2 in maintaining genomic stability through homologous recombination (HRR) |
|
BRCA1 (FANCS), MDC1, and RNF8 are required for BRCA2 (FANCD1) and SLX4 (FANCP) accumulation on the sex chromosomes during meiosis |
|
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair |
|
ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment |
|
both BRCA1 and BARD1 bind DNA and interact with RAD51, and BRCA1-BARD1 enhances the recombinase activity of RAD51 |
|
BRCA1 promotes oxidative metabolism by degrading POU2F1, a transcription factor with proglycolytic and tumorigenic effects |
|
regulation of BRCA1-BARD1 heterodimerization through SIRT2 deacetylation, elucidating a critical upstream signaling event directing BRCA1-BARD1 heterodimerization, which facilitates HR and tumor suppression |
|
novel function of the BRCA1-BARD1 complex in the regulation of TOP2B and Pol II-mediated gene expression |