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FLASH GENE
Symbol BOLL contributors: mct/npt - updated : 17-02-2010
HGNC name boll, boule-like (Drosophila)
HGNC id 14273
Location 2q33.1      Physical location : 198.591.602 - 198.650.938
Synonym name
  • BOULE protein
  • bol (Drosophila boule homolog)-like
  • Synonym symbol(s) BOULE
    DNA
    TYPE functioning gene
    STRUCTURE 59.34 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391470 2 similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) SLC39A10 2q33.1 solute carrier family 39 (zinc transporter), member 10 DNAH7 2q33-1 dynein, axonemal, heavy polypeptide 7 STK17B 2q33.1 serine/threonine kinase 17b (apoptosis-inducing) NEDL2 2q33.1 serine/threonine kinase 17b (apoptosis-inducing) FLJ39660 2q33.1 hypothetical protein FLJ39660 LOC200624 2q33.1 hypothetical LOC200624 DKFZp434P055 2q33.1 hypothetical protein DKFZp434P055 GTF3C3 2q33.1 general transcription factor IIIC, polypeptide 3, 102kDa LOC389068 2 similar to ISPD3024 FLJ12377 LOC91526 2q33.1 hypothetical protein DKFZp434D2328 LOC391471 2 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 SF3B1 2p23.3-q34 splicing factor 3b, subunit 1, 155kDa FLJ13448 2q33.1 hypothetical protein FLJ13448 HSPD1 2q33.1 heat shock 60kDa protein 1 (chaperonin) HSPE1 2q33.1 heat shock 10kDa protein 1 (chaperonin 10) PREI3 2q33.1 preimplantation protein 3 C2orf11 2q33.1 chromosome 2 open reading frame 11 LOC92935 2q33.1 hypothetical protein BC009115 BOLL 2q33.1 bol, boule-like (Drosophila) PLCL1 2q33 phospholipase C-like 1 SATB2 2q32-q33 SATB family member 2 FLJ32063 2q33.1 hypothetical protein FLJ32063 LOC389069 2 similar to selenophosphate synthetase 1 LOC389070 2 LOC389070 FLJ38973 2q33.1 hypothetical protein FLJ38973 FLJ37953 2q33.1 hypothetical protein FLJ37953 FLJ22555 2q33.1 hypothetical protein FLJ22555 DNAPTP6 2q33.2 DNA polymerase-transactivated protein 6 FLJ37818 2q33.2 hypothetical protein FLJ37818 FLJ31322 2q33.2 hypothetical protein FLJ31322 TRIPIN 2q33.2 tripin AOX1 2q33 aldehyde oxidase 1 AOX2 2q33.2 aldehyde oxidase 2
    RNA
    TRANSCRIPTS type messenger
    text three alternatively spliced exons 1
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2779 - 295 only in germ cells Kee (2009)
    11 splicing 2842 31 283 only in germ cells Kee (2009)
  • alternate 5' exon, downstream in frame start codon
  • shorter N terminus
  • major physiological role in complete spermatogenesis and meiotic arrest
  • - - 1270 - 289 only in germ cells Kostova (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single RNA binding domain with signature RNP1 and RNP2 repeats
  • a DAZ-like domain
  • HOMOLOGY
    interspecies homolog to Drosophila Boule
    homolog to murine Boule
    Homologene
    FAMILY
  • RRM DAZ family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text in the cytoplasm of primary spermatocytes
    basic FUNCTION
  • meiotic regulator,required for germ cell development and encoding an RNA-binding protein
  • a key conserved switch that regulates progression of germ cells through meiosis
  • PABP-binding protein that regulate translation in germ cells (Collier 2005)
  • playing an essential role for meiotic transition and thus for haploid germ cells production
  • promote later stages of meiosis and development of haploid gametes (Kee 2009)
  • functioning primarily to promote germ-cell progression to meiosis and formation of haploid germ cells that resemble round spermatids in cellular and molecular characteristics (Kee 2009)
  • stimulates CDC25A translation, and this effect does not involve alteration of mRNA stability (a decreased CDC25A expression caused by lack or decrease of BOLL may be associated with male infertility) (Lin 2009)
  • role in spermiogenesis, the differentiation of round spermatids into mature spermatozoa (Van Gompel 2010)
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in azoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS