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FLASH GENE
Symbol BOLL contributors: mct/npt - updated : 17-02-2010
HGNC name boll, boule-like (Drosophila)
HGNC id 14273
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single RNA binding domain with signature RNP1 and RNP2 repeats
  • a DAZ-like domain
  • HOMOLOGY
    interspecies homolog to Drosophila Boule
    homolog to murine Boule
    Homologene
    FAMILY
  • RRM DAZ family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text in the cytoplasm of primary spermatocytes
    basic FUNCTION
  • meiotic regulator,required for germ cell development and encoding an RNA-binding protein
  • a key conserved switch that regulates progression of germ cells through meiosis
  • PABP-binding protein that regulate translation in germ cells (Collier 2005)
  • playing an essential role for meiotic transition and thus for haploid germ cells production
  • promote later stages of meiosis and development of haploid gametes (Kee 2009)
  • functioning primarily to promote germ-cell progression to meiosis and formation of haploid germ cells that resemble round spermatids in cellular and molecular characteristics (Kee 2009)
  • stimulates CDC25A translation, and this effect does not involve alteration of mRNA stability (a decreased CDC25A expression caused by lack or decrease of BOLL may be associated with male infertility) (Lin 2009)
  • role in spermiogenesis, the differentiation of round spermatids into mature spermatozoa (Van Gompel 2010)
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in azoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS